Neurofluids is a term introduced to define all fluids in the brain and spine such as blood,
cerebrospinal fluid, and interstitial fluid. Neuroscientists in the past millennium have steadily …

The cerebral vasculature is made up of highly specialized structures that assure constant
brain perfusion necessary to meet the very high demand for oxygen and glucose by neurons …

Objective Choroid plexus (CP) is a key regulator in cerebrospinal fluid production, but its
contribution to glymphatic clearance function and association with white matter …

Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of β-amyloid (Aβ)
in the walls of cerebral vessels, leading to complications such as intracerebral hemorrhage …

White matter hyperintensities (WMHs) of presumed vascular origin are one of the imaging
markers of cerebral small-vessel disease, which is prevalent in older individuals and closely …

Chronic cerebral hypoperfusion (CCH) has been acknowledged as a potential contributor to
cognitive dysfunction and brain injury, causing progressive demyelination of white matter …

Blood-brain barrier (BBB) integrity is essential to maintaining brain health. Aging-related
alterations could lead to chronic progressive leakiness of the BBB, which is directly …

Hypertension is a primary risk factor for the progression of cognitive impairment caused by
cerebral small vessel disease, the most common cerebrovascular disease. However, the …

Chronic cerebral hypoperfusion leads to white matter injury (WMI), which subsequently
causes neurodegeneration and even cognitive impairment. However, due to the lack of …

This editorial summarizes advances from the Clearance of Interstitial Fluid and
Cerebrospinal Fluid (CLIC) group, within the Vascular Professional Interest Area (PIA) of the …