Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia
We report results from the Bipolar Exome (BipEx) collaboration analysis of whole-exome
sequencing of 13,933 patients with bipolar disorder (BD) matched with 14,422 controls. We …
sequencing of 13,933 patients with bipolar disorder (BD) matched with 14,422 controls. We …
Genetics of bipolar disorder: insights into its complex architecture and biology from common and rare variants
Bipolar disorder (BD) is a common mental disorder characterized by recurrent mood
episodes, which causes major socioeconomic burdens globally. Though its disease …
episodes, which causes major socioeconomic burdens globally. Though its disease …
[HTML][HTML] Epigenetic signatures relating to disease-associated genotypic burden in familial risk of bipolar disorder
Environmental factors contribute to risk of bipolar disorder (BD), but how environmental
factors impact the development of psychopathology within the context of elevated genetic …
factors impact the development of psychopathology within the context of elevated genetic …
[HTML][HTML] Activating SIRT-1 signalling with the mitochondrial-CoQ10 activator solanesol improves neurobehavioral and neurochemical defects in ouabain-induced …
Bipolar disorder (BD) is a chronic mental illness characterized by mood fluctuations that
range from depressive lows to manic highs. Several studies have linked the downregulation …
range from depressive lows to manic highs. Several studies have linked the downregulation …
Exome sequencing in bipolar disorder reveals shared risk gene AKAP11 with schizophrenia
Here we report results from the Bipolar Exome (BipEx) collaboration analysis of whole
exome sequencing of 13,933 individuals diagnosed with bipolar disorder (BD), matched …
exome sequencing of 13,933 individuals diagnosed with bipolar disorder (BD), matched …
[HTML][HTML] Neurotransmission-related gene expression in the frontal pole is altered in subjects with bipolar disorder and schizophrenia
AM Medina, MH Hagenauer, DM Krolewski… - Translational …, 2023 - nature.com
The frontal pole (Brodmann area 10, BA10) is the largest cytoarchitectonic region of the
human cortex, performing complex integrative functions. BA10 undergoes intensive …
human cortex, performing complex integrative functions. BA10 undergoes intensive …
Rare variants implicate NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder
Bipolar disorder is an often-severe mental health condition characterized by alternation
between extreme mood states of mania and depression. Despite strong heritability and the …
between extreme mood states of mania and depression. Despite strong heritability and the …
[HTML][HTML] Common and rare variant associations with latent traits underlying depression, bipolar disorder, and schizophrenia
Genetic studies in psychiatry have primarily focused on the effects of common genetic
variants, but few have investigated the role of rare genetic variants, particularly for major …
variants, but few have investigated the role of rare genetic variants, particularly for major …
Functional and behavioral effects of de novo mutations in calcium-related genes in patients with bipolar disorder
T Nakamura, K Nakajima, Y Kobayashi… - Human Molecular …, 2021 - academic.oup.com
Bipolar disorder is a common mental illness occurring in approximately 1% of individuals
and requires lifelong treatment. Although genetic factors are known to contribute to this …
and requires lifelong treatment. Although genetic factors are known to contribute to this …
[HTML][HTML] Whole exome sequencing in dense families suggests genetic pleiotropy amongst Mendelian and complex neuropsychiatric syndromes
S Ganesh, A Vemula, S Bhattacharjee, K Mathew… - Scientific Reports, 2022 - nature.com
Abstract Whole Exome Sequencing (WES) studies provide important insights into the
genetic architecture of serious mental illness (SMI). Genes that are central to the shared …
genetic architecture of serious mental illness (SMI). Genes that are central to the shared …