Cytokine signaling represents one of the cornerstones of the immune system, mediating the
complex responses required to facilitate appropriate immune cell development and function …

Decades of research has recognized a solid role for Pim kinases in lymphoproliferative
disorders. Often up-regulated following JAK/STAT and tyrosine kinase receptor signaling …

The IL (interleukin)-6-type cytokines IL-6, IL-11, LIF (leukaemia inhibitory factor), OSM
(oncostatin M), ciliary neurotrophic factor, cardiotrophin-1 and cardiotrophin-like cytokine are …

Suppressor of cytokine signalling (SOCS) proteins are inhibitors of cytokine signalling
pathways. Studies have shown that SOCS proteins are key physiological regulators of both …

Pim oncogenes are overexpressed in a wide range of tumours from a haematological and
epithelial origin. Pim genes encode serine/threonine kinases that have been shown to …

The identification as cooperating targets of Proviral Integrations of Moloney virus in murine
lymphomas suggested early on that PIM serine/threonine kinases play an important role in …

Although CD8+ T cells undergo autonomous clonal proliferation after antigen stimulation in
vivo, the expansion of activated CD4+ T cells is limited by intrinsic factors that are poorly …

Background Fatal trauma is one of the leading causes of death in Western industrialized
countries. The aim of the present study was to determine the preventability of traumatic …

IL-6 a multi-functional cytokine with important effects in both inflammation and
haematopoiesis. SOCS3 is the primary inhibitor of IL-6 signalling, interacting with gp130, the …

The human pim-1 gene encodes a serine/threonine kinase, which belongs to the group of
calcium/calmodulin-regulated kinases (CAMK). It contains a characteristic kinase domain, a …