Short interfering RNAs (siRNA) are a powerful class of genetic medicines whose clinical
translation can be hindered by their suboptimal delivery properties in vivo. Here, we provide …

The formation of secondary tumors by circulating cancer cells (blood-borne metastasis)
correlates with an increased tendency of the cells to form emboli by aggregation with other …

We performed subtractive and differential hybridization for transcript comparison between
murine fibroblasts and isogenic epithelium, and observed only a few novel intracellular …

We present, here, evidence that foreign DNA can be specifically delivered to cells by a
soluble carrier system that takes advantage of receptor-mediated endocytosis. Our …

At pH 5.4 apotransferrin (iron-free transferrin) binds to cell-surface transferrin receptors to
the same extent and with the same affinity as does diferric transferrin at pH 7.0 …

Exosomes are membrane nanoparticles containing biological substances that are employed
as therapeutics in experimental inflammatory models. Surface modification of exosomes for …

Growing HepG2 cells contain 50,000 functional surface transferrin-binding sites
(Ciechanover, A., Schwartz, AL, and Lodish, HF (1983) Cell 32,267-275) and 100,000 …

Hepatitis B virus (HBV) has not yet been propagated in vitro, and knowledge concerning its
reaction with receptors on target cells remained scant. We have located within the HBV …

Aberrant forms of the anaplastic lymphoma kinase (ALK) have been implicated in the
pathogenesis of multiple human cancers, where ALK represents a rational therapeutic target …

In our attempt to assess the topology of glucosylceramide biosynthesis, we have employed a
truncated ceramide analogue that permeates cell membranes and is converted into water …