Current approaches to malaria vaccines
PE Duffy - Current opinion in microbiology, 2022 - Elsevier
Highlights•First malaria vaccine RTS, S induces anti-sporozoite antibodies to protect
children.•Whole-sporozoite vaccines induce T cells and antibodies and confer field …
children.•Whole-sporozoite vaccines induce T cells and antibodies and confer field …
Antibodies against Plasmodium falciparum malaria at the molecular level
JP Julien, H Wardemann - Nature Reviews Immunology, 2019 - nature.com
Malaria is a vector-borne disease of global importance, with the vast majority of its life-
threatening cases caused by infection with Plasmodium falciparum parasites. Repeated …
threatening cases caused by infection with Plasmodium falciparum parasites. Repeated …
[HTML][HTML] A potent anti-malarial human monoclonal antibody targets circumsporozoite protein minor repeats and neutralizes sporozoites in the liver
LT Wang, LS Pereira, Y Flores-Garcia, J O'Connor… - Immunity, 2020 - cell.com
Discovering potent human monoclonal antibodies (mAbs) targeting the Plasmodium
falciparum circumsporozoite protein (PfCSP) on sporozoites (SPZ) and elucidating their …
falciparum circumsporozoite protein (PfCSP) on sporozoites (SPZ) and elucidating their …
Mapping functional humoral correlates of protection against malaria challenge following RTS, S/AS01 vaccination
TJ Suscovich, JK Fallon, J Das, AR Demas… - Science translational …, 2020 - science.org
Vaccine development has the potential to be accelerated by coupling tools such as systems
immunology analyses and controlled human infection models to define the protective …
immunology analyses and controlled human infection models to define the protective …
Malaria: influence of Anopheles mosquito saliva on Plasmodium infection
Malaria is caused by Plasmodium protozoa that are transmitted by anopheline mosquitoes.
Plasmodium sporozoites are released with saliva when an infected female mosquito takes a …
Plasmodium sporozoites are released with saliva when an infected female mosquito takes a …
[HTML][HTML] Five decades of clinical assessment of whole-sporozoite malaria vaccines
In 1967, pioneering work by Ruth Nussenzweig demonstrated for the first time that irradiated
sporozoites of the rodent malaria parasite Plasmodium berghei protected mice against a …
sporozoites of the rodent malaria parasite Plasmodium berghei protected mice against a …
Sporozoite immunization: innovative translational science to support the fight against malaria
TL Richie, LWP Church, T Murshedkar… - Expert review of …, 2023 - Taylor & Francis
Introduction Malaria, a devastating febrile illness caused by protozoan parasites, sickened
247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in …
247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in …
[HTML][HTML] Plasmodium falciparum Malaria Vaccines and Vaccine Adjuvants
Malaria—a parasite vector-borne disease—is a global health problem, and Plasmodium
falciparum has proven to be the deadliest among Plasmodium spp., which causes malaria in …
falciparum has proven to be the deadliest among Plasmodium spp., which causes malaria in …
Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs
The circumsporozoite protein of the human malaria parasite Plasmodium falciparum
(PfCSP) is the main target of antibodies that prevent the infection and disease, as shown in …
(PfCSP) is the main target of antibodies that prevent the infection and disease, as shown in …
[HTML][HTML] Cytotoxicity of human antibodies targeting the circumsporozoite protein is amplified by 3D substrate and correlates with protection
MC Aguirre-Botero, LT Wang, P Formaglio… - Cell reports, 2023 - cell.com
Human monoclonal antibodies (hmAbs) targeting the Plasmodium falciparum
circumsporozoite protein (PfCSP) on the sporozoite surface are a promising tool for …
circumsporozoite protein (PfCSP) on the sporozoite surface are a promising tool for …