The physiological functions of human peroxisomes

RJA Wanders, M Baes, D Ribeiro… - Physiological …, 2023 - journals.physiology.org
Peroxisomes are subcellular organelles that play a central role in human physiology by
catalyzing a range of unique metabolic functions. The importance of peroxisomes for human …

Subcellular proteomics

JA Christopher, C Stadler, CE Martin… - Nature Reviews …, 2021 - nature.com
The eukaryotic cell is compartmentalized into subcellular niches, including membrane-
bound and membrane-less organelles. Proteins localize to these niches to fulfil their …

A cross-talk between epithelium and endothelium mediates human alveolar–capillary injury during SARS-CoV-2 infection

P Wang, R Luo, M Zhang, Y Wang, T Song, T Tao… - Cell death & …, 2020 - nature.com
Abstract COVID-19, caused by SARS-CoV-2, is an acute and rapidly developing pandemic,
which leads to a global health crisis. SARS-CoV-2 primarily attacks human alveoli and …

Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages

E Pellegrino, B Aylan, C Bussi, A Fearns… - Journal of Cell …, 2023 - rupress.org
Peroxisomes are organelles involved in many metabolic processes including lipid
metabolism, reactive oxygen species (ROS) turnover, and antimicrobial immune responses …

Peroxisomes as cellular adaptors to metabolic and environmental stress

A He, JM Dean, IJ Lodhi - Trends in cell biology, 2021 - cell.com
Peroxisomes are involved in multiple metabolic processes, including fatty acid oxidation,
ether lipid synthesis, and reactive oxygen species (ROS) metabolism. Recent studies …

Peroxisomes in immune response and inflammation

F Di Cara, P Andreoletti, D Trompier, A Vejux… - International journal of …, 2019 - mdpi.com
The immune response is essential to protect organisms from infection and an altered self. An
organism's overall metabolic status is now recognized as an important and long-overlooked …

COVID‐19 induces neuroinflammation and suppresses peroxisomes in the brain

A Roczkowsky, D Limonta, JP Fernandes… - Annals of …, 2023 - Wiley Online Library
Objective Peroxisome injury occurs in the central nervous system (CNS) during multiple
virus infections that result in neurological disabilities. We investigated host neuroimmune …

Restructured membrane contacts rewire organelles for human cytomegalovirus infection

KC Cook, E Tsopurashvili, JM Needham… - Nature …, 2022 - nature.com
Membrane contact sites (MCSs) link organelles to coordinate cellular functions across space
and time. Although viruses remodel organelles for their replication cycles, MCSs remain …

Temporal dynamics of protein complex formation and dissociation during human cytomegalovirus infection

Y Hashimoto, X Sheng, LA Murray-Nerger… - Nature …, 2020 - nature.com
The co-evolution and co-existence of viral pathogens with their hosts for millions of years is
reflected in dynamic virus-host protein-protein interactions (PPIs) that are intrinsic to the …

Virus impact on lipids and membranes

E Ketter, G Randall - Annual review of virology, 2019 - annualreviews.org
Viruses manipulate cellular lipids and membranes at each stage of their life cycle. This
includes lipid-receptor interactions, the fusion of viral envelopes with cellular membranes …