Cancer-associated cachexia is a disorder characterized by loss of body weight with specific
losses of skeletal muscle and adipose tissue. Cachexia is driven by a variable combination …

Cancer cachexia is characterized by a significant reduction in body weight resulting
predominantly from loss of adipose tissue and skeletal muscle. Cachexia causes reduced …

Most patients with pancreatic adenocarcinoma (PDAC) suffer cachexia; some do not. To
model heterogeneity, we used patient-derived orthotopic xenografts. These phenocopied …

Muscle wasting occurs in a variety of conditions, including both genetic diseases, such as
muscular dystrophies, and acquired disorders, ranging from muscle disuse to cancer …

Extracellular superoxide dismutase (EcSOD) is the only extracellular scavenger of
superoxide anion (O 2.-) with unique binding capacity to cell surface and extracellular matrix …

Muscle wasting and cachexia have long been postulated to be key determinants of cancer-
related death, but there has been no direct experimental evidence to substantiate this …

Up to 50% of cancer patients suffer from a progressive atrophy of adipose tissue and
skeletal muscle, called cachexia, resulting in weight loss, a reduced quality of life, and a …

Background Preoperative risk assessment in cancer surgery is of importance to improve
treatment and outcome. The aim of this study was to assess the impact of CT-assessed …

Cancer cachexia is a systemic hypoanabolic and catabolic syndrome that diminishes the
quality of life of cancer patients, decreases the efficiency of therapeutic strategies and …

Fibroblast activation protein-α (FAP) identifies stromal cells of mesenchymal origin in human
cancers and chronic inflammatory lesions. In mouse models of cancer, they have been …