Significance: Fibrosis is the endpoint of chronic disease in multiple organs, including the
skin, heart, lungs, intestine, liver, and kidneys. Pathologic accumulation of fibrotic tissue …

Cardiovascular disease is the leading cause of death worldwide, both in the general
population and among patients with chronic kidney disease (CKD). In most cases, the …

Macrophages populate the healthy myocardium and, depending on their phenotype, may
contribute to tissue homeostasis or disease. Their origin and role in diastolic dysfunction, a …

Atherosclerosis is an inflammatory disease within the arterial wall that is responsible for
several important adverse vascular events, including coronary artery disease, myocardial …

Atherosclerosis contributes to the development of many cardiovascular diseases, which
remain the leading cause of death in developed countries. Atherosclerosis is a chronic …

A number of widespread and devastating chronic diseases, including atherosclerosis, type 2
diabetes, and Alzheimer's disease, have a pathophysiologically important inflammatory …

Inflammation is essential in the initial development and progression of many cardiovascular
diseases involving innate and adaptive immune responses. The role of CD4+ CD25+ …

According to the traditional view, atherosclerosis results from a passive buildup of
cholesterol in the artery wall. Yet, burgeoning evidence implicates inflammation and immune …

The intestine has a major role in the digestion and absorption of nutrients, and gut barrier is
the first defense line against harmful pathogens. Alteration of the intestinal barrier is …

Inflammation, Atherosclerosis, and Coronary Artery Disease | New England Journal of Medicine
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