[HTML][HTML] Role of the tumor microenvironment in tumor progression and the clinical applications

Y Yuan, YC Jiang, CK Sun… - Oncology reports, 2016 - spandidos-publications.com
Oncogene activation and tumor-suppressor gene inactivation are considered as the main
causes driving the transformation of normal somatic cells into malignant tumor cells. Cancer …

The senescence-associated secretory phenotype: the dark side of tumor suppression

JP Coppé, PY Desprez, A Krtolica… - Annual review of …, 2010 - annualreviews.org
Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at
risk for malignant transformation. However, accumulating evidence shows that senescent …

[HTML][HTML] Tumor self-seeding by circulating cancer cells

MY Kim, T Oskarsson, S Acharyya, DX Nguyen… - Cell, 2009 - cell.com
Cancer cells that leave the primary tumor can seed metastases in distant organs, and it is
thought that this is a unidirectional process. Here we show that circulating tumor cells …

[HTML][HTML] Cancer and the chemokine network

F Balkwill - Nature Reviews Cancer, 2004 - nature.com
A complex network of chemokines and their receptors influences the development of primary
tumours and metastases. New information about the biological role of chemokines in these …

Comprehensive assessment of cellular senescence in the tumor microenvironment

X Wang, L Ma, X Pei, H Wang, X Tang… - Briefings in …, 2022 - academic.oup.com
Cellular senescence (CS), a state of permanent growth arrest, is intertwined with
tumorigenesis. Due to the absence of specific markers, characterizing senescence levels …

Senescent cells as a source of inflammatory factors for tumor progression

AR Davalos, JP Coppe, J Campisi… - Cancer and Metastasis …, 2010 - Springer
Cellular senescence, which is associated with aging, is a process by which cells enter a
state of permanent cell cycle arrest, therefore constituting a potent tumor suppressive …

Chemokines in health and disease

D Raman, T Sobolik-Delmaire, A Richmond - Experimental cell research, 2011 - Elsevier
Chemokines and their receptors play a key role in development and homeostasis as well as
in the pathogenesis of tumors and autoimmune diseases. Chemokines are involved in the …

The role of CXC chemokines and their receptors in cancer

J Vandercappellen, J Van Damme, S Struyf - Cancer letters, 2008 - Elsevier
Chemokines, or chemotactic cytokines, and their receptors have been discovered as
essential and selective mediators in leukocyte migration to inflammatory sites and to …

Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor

B Toh, X Wang, J Keeble, WJ Sim, K Khoo… - PLoS …, 2011 - journals.plos.org
In order to metastasize, cancer cells need to acquire a motile phenotype. Previously,
development of this phenotype was thought to rely on the acquisition of selected, random …

Role of chemokines in tumor growth

D Raman, PJ Baugher, YM Thu, A Richmond - Cancer letters, 2007 - Elsevier
Chemokines play a paramount role in the tumor progression. Chronic inflammation
promotes tumor formation. Both tumor cells and stromal cells elaborate chemokines and …