Omics-based technologies have revolutionized our understanding of the coding potential of
the genome. In particular, these studies revealed widespread unannotated open reading …

Hepatocellular carcinoma (HCC) is the most frequent subtype of primary liver cancer and
one of the leading causes of cancer-related death worldwide. However, the molecular …

Circular RNAs (circRNAs) have emerged as crucial regulators in physiology and human
diseases. However, evolutionarily conserved circRNAs with potent functions in cancers are …

An exciting emerging topic in the noncoding RNA (ncRNA) field is the discovery of short
peptides called micropeptides (≤ 100 amino acids), whose novel therapeutic opportunities …

Diabetic cardiomyopathy (DCM) is a common complication in diabetic patients. The
molecular mechanisms of DCM remain to be fully elucidated. The intronic long noncoding …

Long non-coding RNAs (lncRNAs) were originally defined as non-coding RNAs (ncRNAs)
which lack protein-coding ability. However, with the emergence of technologies such as …

Long non-coding RNAs (lncRNAs) have been identified as master gene regulators through
various mechanisms such as transcription, translation, protein modification and RNA-protein …

Polypeptides encoded by long noncoding RNAs (lncRNAs) are a novel class of functional
molecules. However, whether these hidden polypeptides participate in the TP53 pathway …

Chimeric antigen receptor (CAR) T cell is a novel approach, which utilizes anti-tumor
immunity for cancer treatment. As compared to the traditional cell-mediated immunity, CAR-T …

Neoplastic cells need to adapt their gene expression pattern to survive in an ever-changing
or unfavorable tumor microenvironment. Protein synthesis (or mRNA translation), an …