Chronic lymphocytic leukaemia
G Dighiero, TJ Hamblin - The Lancet, 2008 - thelancet.com
Chronic lymphocytic leukaemia is the commonest form of leukaemia in Europe and North
America, and mainly, though not exclusively, affects older individuals. It has a very variable …
America, and mainly, though not exclusively, affects older individuals. It has a very variable …
Chronic lymphocytic leukemia
N Chiorazzi, SS Chen, KR Rai - Cold Spring …, 2021 - perspectivesinmedicine.cshlp.org
Patients with chronic lymphocytic leukemia can be divided into three categories: those who
are minimally affected by the problem, often never requiring therapy; those that initially …
are minimally affected by the problem, often never requiring therapy; those that initially …
Two levels of protection for the B cell genome during somatic hypermutation
Somatic hypermutation introduces point mutations into immunoglobulin genes in germinal
centre B cells during an immune response. The reaction is initiated by cytosine deamination …
centre B cells during an immune response. The reaction is initiated by cytosine deamination …
Tumors of the hemolymphatic system
VE Valli, D Bienzle, DJ Meuten - Tumors in domestic animals, 2016 - Wiley Online Library
The two general groups for tumors of the hemolymphatic system are lymphoid (lymphoma
and leukemia) and myeloid leukemias. The tumors in each can be characterized by their …
and leukemia) and myeloid leukemias. The tumors in each can be characterized by their …
Biological and clinical risk factors of chronic lymphocytic leukaemia transformation to Richter syndrome
D Rossi, M Cerri, D Capello… - British journal of …, 2008 - Wiley Online Library
Predictors of chronic lymphocytic leukaemia (CLL) transformation to Richter syndrome (RS)
are not established and were investigated in 185 consecutive CLL cases. Actuarial …
are not established and were investigated in 185 consecutive CLL cases. Actuarial …
Stereotyped B-cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome
Purpose: Few biological prognosticators are useful for prediction of Richter syndrome (RS),
representing the transformation of chronic lymphocytic leukemia (CLL) to aggressive …
representing the transformation of chronic lymphocytic leukemia (CLL) to aggressive …
Role of AID in tumorigenesis
I Okazaki, A Kotani, T Honjo - Advances in immunology, 2007 - Elsevier
A hallmark of mature B‐cell lymphomas is reciprocal chromosomal translocations involving
the Ig locus and a proto‐oncogene, which usually result in the deregulated, constitutive …
the Ig locus and a proto‐oncogene, which usually result in the deregulated, constitutive …
Richter syndrome: molecular insights and clinical perspectives
D Rossi, G Gaidano - Hematological oncology, 2009 - Wiley Online Library
Richter syndrome (RS) represents the clinico‐pathologic transformation of chronic
lymphocytic leukaemia (CLL) to an aggressive lymphoma, most commonly diffuse large B …
lymphocytic leukaemia (CLL) to an aggressive lymphoma, most commonly diffuse large B …
Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma
D Rossi, E Berra, M Cerri, C Deambrogi… - …, 2006 - haematologica.org
The molecular mechanisms involved in histologic transformation of follicular lymphoma (FL)
and B-chronic lymphocytic leukemia (B-CLL) to diffuse large B-cell lymphoma (DLBCL) are …
and B-chronic lymphocytic leukemia (B-CLL) to diffuse large B-cell lymphoma (DLBCL) are …
Richter syndrome in chronic lymphocytic leukemia: updates on biology, clinical features and therapy
Richter syndrome (RS) or Richter transformation is the development of secondary
aggressive lymphoma in the setting of underlying chronic lymphocytic leukemia/small …
aggressive lymphoma in the setting of underlying chronic lymphocytic leukemia/small …