Abstract The international American Joint Committee on Cancer/Union for International
Cancer Control (AJCC/UICC) tumour-node-metastasis (TNM) staging system provides the …

Macrophages are crucial drivers of tumour-promoting inflammation. Tumour-associated
macrophages (TAMs) contribute to tumour progression at different levels: by promoting …

Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were
originally thought to be intracellular signaling pathways that mediate cytokine signals in …

Signal transducer and activator of transcription (STAT) 1 is part of the Janus kinase
(JAK)/STAT signalling cascade and is best known for its essential role in mediating …

The hallmark t (14; 18)(q32; q21) in follicular lymphoma (FL) results in constitutive
overexpression of the BCL2 protein, allowing B cells to abrogate the default germinal center …

Tumour‐associated macrophages (TAM s) represent a predominant population of
inflammatory cells that present in solid tumours. TAM s are mostly characterized as …

The transcription factors STAT1 and STAT3 appear to play opposite roles in tumorigenesis.
While STAT3 promotes cell survival/proliferation, motility and immune tolerance and is …

Purpose High amounts of intratumoral macrophages have been shown to correlate with
poor prognosis in patients with follicular lymphoma (FL) treated with chemotherapy without …

Previous studies of follicular lymphoma (FL) patients treated heterogeneously have
suggested that decreased numbers of regulatory T cells correlates with improved survival …

Surface Ig (sIg) of follicular lymphoma (FL) is vital for tumor cell survival. We found
previously that the Ig in FL is unusual, because the variable region genes carry sequence …