Exosomes based strategies for brain drug delivery

FU Rehman, Y Liu, M Zheng, B Shi - Biomaterials, 2023 - Elsevier
Exosome application has emerged as a promising nanotechnology discipline for various
diseases therapeutics and diagnoses. Owing to the natural properties of efficient drug …

Concise review: MSC-derived exosomes for cell-free therapy

DG Phinney, MF Pittenger - Stem cells, 2017 - academic.oup.com
Mesenchymal stem cell transplantation is undergoing extensive evaluation as a cellular
therapy in human clinical trials. Because MSCs are easily isolated and amenable to culture …

Extracellular vesicles as personalized medicine

DJ Beetler, DN Di Florio, KA Bruno, T Ikezu… - Molecular aspects of …, 2023 - Elsevier
Extracellular vesicles (EVs) are released from all cells in the body, forming an important
intercellular communication network that contributes to health and disease. The contents of …

Exosome-mediated delivery of hydrophobically modified siRNA for huntingtin mRNA silencing

MC Didiot, LM Hall, AH Coles, RA Haraszti… - Molecular Therapy, 2016 - cell.com
Delivery represents a significant barrier to the clinical advancement of oligonucleotide
therapeutics for the treatment of neurological disorders, such as Huntington's disease …

Use of lung-specific exosomes for miRNA-126 delivery in non-small cell lung cancer

H Nie, X Xie, D Zhang, Y Zhou, B Li, F Li, F Li, Y Cheng… - Nanoscale, 2020 - pubs.rsc.org
Engineered exosomes have become popular drug delivery carriers for cancer treatment.
This is partially due to the interesting property, ie exosome organotropism, which plays an …

Role of exosomes in central nervous system diseases

W Liu, X Bai, A Zhang, J Huang, S Xu… - Frontiers in molecular …, 2019 - frontiersin.org
There are many types of intercellular communication, and extracellular vesicles are one of
the important forms of this. They are released by a variety of cell types, are heterogeneous …

The emerging antioxidant paradigm of mesenchymal stem cell therapy

R Stavely, K Nurgali - Stem Cells Translational Medicine, 2020 - academic.oup.com
Mesenchymal stem cells (multipotent stromal cells; MSCs) have been under investigation for
the treatment of diverse diseases, with many promising outcomes achieved in animal …

Recent advances in biomimetic nanodelivery systems: new brain-targeting strategies

J Liao, L Fan, Y Li, QQ Xu, LY Xiong, SS Zhang… - Journal of Controlled …, 2023 - Elsevier
In recent years, brain diseases have seriously threatened human health due to their high
morbidity and mortality. Achieving efficient drug delivery to provide satisfactory therapeutic …

Stem cell-derived exosomes: a new strategy of neurodegenerative disease treatment

N Fayazi, M Sheykhhasan, S Soleimani Asl… - Molecular …, 2021 - Springer
Short-term symptomatic treatment and dose-dependent side effects of pharmacological
treatment for neurodegenerative diseases have forced the medical community to seek an …

Extracellular vesicles, from the pathogenesis to the therapy of neurodegenerative diseases

X Xia, Y Wang, JC Zheng - Translational Neurodegeneration, 2022 - Springer
Extracellular vesicles (EVs) are small bilipid layer-enclosed vesicles that can be secreted by
all tested types of brain cells. Being a key intercellular communicator, EVs have emerged as …