Oligosaccharides and glycoconjugates play an important role in biological processes. The
use of these complex polymers as biocompatible materials for medicinal applications as well …

Heparanase, an only endo-β-d-glucuronidase capable of cleaving heparan sulfate (HS) side
chains at specific sites, contributes to remodeling of the extracellular matrix (ECM) and …

Heparan sulfate (HS) is a highly sulfated glycosaminoglycan with a variety of critical
functions in cell signaling and regulation. HS oligosaccharides can mimic or interfere with …

Azasugar analogues of l‐iduronic acid (l‐IdoA) and d‐glucuronic acid (d‐GlcA) and their
corresponding enantiomers have been synthesized as potential pharmacological …

Background: An endo-β-glucuronidase enzyme, Heparanase (HPSE), degrades the side
chains of polymeric heparan sulfate (HS), a glycosaminoglycan formed by alternate …

Herein, we present an alternative and elegant synthetic approach toward powerful β-
glucosidase inhibitor isofagomine. Derivatizations of the ring nitrogen provided a selected …

D-Glucosamine derivatives bearing latent O4 functionality provide modified H/HS-type
disaccharide donors for a final stage capping approach enabling introduction of conjugation …

Fondaparinux, a synthetic pentasaccharide anticoagulant based on heparin antithrombin-
binding domain, is derived from a chemical synthesis with more than 50 steps. Herein, we …

Increasing knowledge of how peptides bind saccharides, and of how saccharides bind
peptides, is starting to revolutionize understanding of cell‐extracellular matrix relationships …

Heparanase (HPSE)-directed tumor progression plays a crucial role in mediating tumor-host
crosstalk and priming the tumor microenvironment, leading to tumor growth, metastasis and …