Biobanks facilitate genome-wide association studies (GWASs), which have mapped
genomic loci across a range of human diseases and traits. However, most biobanks are …

Abstract The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been
established to develop a public resource of genetic regulatory variants in livestock, which is …

Most transcriptome-wide association studies (TWASs) so far focus on European ancestry
and lack diversity. To overcome this limitation, we aggregated genome-wide association …

Methods integrating genetics with transcriptomic reference panels prioritize risk genes and
mechanisms at only a fraction of trait-associated genetic loci, due in part to an overreliance …

Proteome-wide Mendelian randomization (MR) shows value in prioritizing drug targets in
Europeans but with limited evidence in other ancestries. Here, we present a multi-ancestry …

Transcriptome‐wide association study (TWAS) methodologies aim to identify genetic effects
on phenotypes through the mediation of gene transcription. In TWAS, in silico models of …

Integrative analysis of genome-wide association studies (GWASs) and gene expression
studies in the form of a transcriptome-wide association study (TWAS) has the potential to …

Transcriptome prediction models built with data from European-descent individuals are less
accurate when applied to different populations because of differences in linkage …

Transcriptome-wide association studies (TWAS) have provided valuable insight in
identifying genes that may impact cigarette smoking. Most of previous studies, however …

Recent studies have highlighted the essential role of RNA splicing, a key mechanism of
alternative RNA processing, in establishing connections between genetic variations and …