Diabetic nephropathy (DN) is the leading cause of end-stage renal disease globally. The
primary initiating mechanism in DN is hyperglycemia-induced vascular dysfunction, but its …

Host sensing in the gut microbiota has been crucial in the regulation of intestinal
homeostasis. Although inflammatory bowel diseases (IBDs), multifactorial chronic …

Background Previous studies have reported that gut microbiota, permeability, short-chain
fatty acids (SCFAs), and inflammation are altered in Parkinson's disease (PD), but how these …

Abstract Background and Aims Faecal biomarkers, particularly calprotectin [FCAL], have
become important diagnostic and monitoring tools in inflammatory bowel diseases [IBD]. As …

The signaling network between cancer and stromal cells plays a crucial role in tumor
microenvironment. The fate of tumor progression mainly depends on the huge amount of …

Lipocalin 2 (LCN2) mediates key roles in innate immune responses. It has affinity for many
lipophilic ligands and binds various siderophores, thereby limiting bacterial growth by iron …

Serotonin is a highly conserved and ubiquitous signaling molecule involved in a vast variety
of biological processes. A majority of serotonin is produced in the gastrointestinal …

Emerging evidences indicate a critical role of the gut microbiota in etiopathogenesis of
dementia, a debilitating multifactorial disorder characterized by progressive deterioration of …

Background The epithelium in the colonic mucosa is implicated in the pathophysiology of
various diseases, including inflammatory bowel diseases and colorectal cancer. Intestinal …

We hypothesized that the antimicrobial peptide cathelicidin has a physiological role in
regulating gut inflammatory homeostasis. We determined that cathelicidin synergizes with …