Citrus aurantium L.(bitter orange) extracts that contain p‐synephrine as the primary
protoalkaloid are widely used for weight loss/weight management, sports performance …

Octopamine (OCT) belongs to a group of compounds known as biogenic amines. OCT, a
monohydroxylic analog of norepinephrine, is found in both vertebrate and invertebrate …

Obesity is a major health problem facing the developed and developing world. Efforts by
individuals, health professionals, educators, and policy makers to combat the escalating …

The p-synephrine is the principal phytochemical found in bitter orange (Citrus aurantium).
This substance is widely included in dietary supplements for weight loss/body fat reduction …

Citrus aurantium (bitter orange) extract and its principal protoalkaloidal constituent p‐
synephrine are widely used in weight loss and weight management as well as in sports …

A cloned seven transmembrane‐spanning Drosophila octopamine/tyramine receptor,
permanently expressed in a Chinese hamster ovary cell line, both inhibits adenylate cyclase …

The multi‐billion dollar dietary supplement industry is global in reach. The industry has been
criticized for problems related to poor quality control, safety, misbranding, and adulteration …

PURPOSE: Ephedra-free weight loss dietary supplements containing bitter orange (Citrus
aurantium), a botanical source of the adrenergic amines synephrine and octopamine, have …

Synephrine is cited as 'the active component'of plants and dietary supplements used in
weight loss. It became one of the most popular stimulants present in weight-loss products …

Confusion and misunderstanding exist regarding the lack of cardiovascular and other
adverse health effects of p‐synephrine and p‐octopamine relative to ephedrine and m …