Genetics of human brain development

Y Zhou, H Song, G Ming - Nature Reviews Genetics, 2024 - nature.com
Brain development in humans is achieved through precise spatiotemporal genetic control,
the mechanisms of which remain largely elusive. Recently, integration of technological …

New insights into the development of the human cerebral cortex

Z Molnár, GJ Clowry, N Šestan, A Alzu'bi… - Journal of …, 2019 - Wiley Online Library
The cerebral cortex constitutes more than half the volume of the human brain and is
presumed to be responsible for the neuronal computations underlying complex phenomena …

[HTML][HTML] Human pluripotent stem cell-derived neural cells and brain organoids reveal SARS-CoV-2 neurotropism predominates in choroid plexus epithelium

F Jacob, SR Pather, WK Huang, F Zhang, SZH Wong… - Cell stem cell, 2020 - cell.com
Neurological complications are common in patients with COVID-19. Although severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal pathogen of COVID-19, has …

The use of brain organoids to investigate neural development and disease

E Di Lullo, AR Kriegstein - Nature Reviews Neuroscience, 2017 - nature.com
Understanding the development and dysfunction of the human brain is a major goal of
neurobiology. Much of our current understanding of human brain development has been …

[HTML][HTML] Brain-region-specific organoids using mini-bioreactors for modeling ZIKV exposure

X Qian, HN Nguyen, MM Song, C Hadiono, SC Ogden… - Cell, 2016 - cell.com
Cerebral organoids, three-dimensional cultures that model organogenesis, provide a new
platform to investigate human brain development. High cost, variability, and tissue …

Zika virus and birth defects—reviewing the evidence for causality

SA Rasmussen, DJ Jamieson, MA Honein… - … England Journal of …, 2016 - Mass Medical Soc
Zika Virus and Birth Defects — Reviewing the Evidence for Causality | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

Characterizing the pattern of anomalies in congenital Zika syndrome for pediatric clinicians

CA Moore, JE Staples, WB Dobyns, A Pessoa… - JAMA …, 2017 - jamanetwork.com
Importance Zika virus infection can be prenatally passed from a pregnant woman to her
fetus. There is sufficient evidence to conclude that intrauterine Zika virus infection is a cause …

[HTML][HTML] An update on Zika virus infection

D Baud, DJ Gubler, B Schaub, MC Lanteri, D Musso - The Lancet, 2017 - thelancet.com
The epidemic history of Zika virus began in 2007, with its emergence in Yap Island in the
western Pacific, followed in 2013–14 by a larger epidemic in French Polynesia, south …

[HTML][HTML] The Brazilian Zika virus strain causes birth defects in experimental models

FR Cugola, IR Fernandes, FB Russo, BC Freitas… - Nature, 2016 - nature.com
Zika virus (ZIKV) is an arbovirus belonging to the genus Flavivirus (family Flaviviridae) and
was first described in 1947 in Uganda following blood analyses of sentinel Rhesus …

[HTML][HTML] The emergence of Zika virus and its new clinical syndromes

TC Pierson, MS Diamond - Nature, 2018 - nature.com
Zika virus (ZIKV) is a mosquito-transmitted flavivirus that has emerged as a global health
threat because of its potential to generate explosive epidemics and ability to cause …