Chemical tools to investigate mechanisms associated with HSP90 and HSP70 in disease

L Shrestha, HJ Patel, G Chiosis - Cell chemical biology, 2016 - cell.com
The chaperome is a large and diverse protein machinery composed of chaperone proteins
and a variety of helpers, such as the co-chaperones, folding enzymes, and scaffolding and …

Regulatory functions of hypoxia in host–parasite interactions: a focus on enteric, tissue, and blood protozoa

E DeMichele, O Sosnowski, AG Buret, T Allain - Microorganisms, 2023 - mdpi.com
Body tissues are subjected to various oxygenic gradients and fluctuations and hence can
become transiently hypoxic. Hypoxia-inducible factor (HIF) is the master transcriptional …

Queuine is a nutritional regulator of Entamoeba histolytica response to oxidative stress and a virulence attenuator

S Nagaraja, MW Cai, J Sun, H Varet, L Sarid… - Mbio, 2021 - Am Soc Microbiol
Queuosine is a naturally occurring modified ribonucleoside found in the first position of the
anticodon of the transfer RNAs for Asp, Asn, His, and Tyr. Eukaryotes lack pathways to …

Pathogenicity and virulence of Entamoeba histolytica, the agent of amoebiasis

N Guillén - Virulence, 2023 - Taylor & Francis
The amoeba parasite Entamoeba histolytica is the causative agent of human amebiasis, an
enteropathic disease affecting millions of people worldwide. This ancient protozoan is an …

Extensive transcriptome analysis correlates the plasticity of Entamoeba histolytica pathogenesis to rapid phenotype changes depending on the environment

C Weber, M Koutero, MA Dillies, H Varet… - Scientific reports, 2016 - nature.com
Amoebiasis is a human infectious disease due to the amoeba parasite Entamoeba
histolytica. The disease appears in only 20% of the infections. Diversity in phenotypes may …

Utilization of Different Omic Approaches to Unravel Stress Response Mechanisms in the Parasite Entamoeba histolytica

S Nagaraja, S Ankri - Frontiers in Cellular and Infection Microbiology, 2018 - frontiersin.org
During its life cycle, the unicellular parasite Entamoeba histolytica is challenged by a wide
variety of environmental stresses, such as fluctuation in glucose concentration, changes in …

Differential expression of pathogenic genes of Entamoeba histolytica vs E. dispar in a model of infection using human liver tissue explants

C Ximénez, E González, M Nieves, U Magaña… - PLoS …, 2017 - journals.plos.org
We sought to establish an ex vivo model for examining the interaction of E. histolytica with
human tissue, using precision-cut liver slices (PCLS) from donated organs. E. histolytica-or …

Phosphorylation of Eukaryotic Initiation Factor-2α during Stress and Encystation in Entamoeba Species

HM Hendrick, BH Welter, MA Hapstack… - PLoS …, 2016 - journals.plos.org
Entamoeba histolytica is an enteric pathogen responsible for amoebic dysentery and liver
abscess. It alternates between the host-restricted trophozoite form and the infective …

Rabeprazole inhibits several functions of Entamoeba histolytica related with its virulence

Y Martínez-Pérez, M Nequiz-Avendaño… - Parasitology …, 2020 - Springer
Amoebiasis is a human parasitic disease caused by Entamoeba histolytica. The parasite
can invade the large intestine and other organs such as liver; resistance to the host tissue …

Lysine Methyltransferase EhPKMT2 Is Involved in the In Vitro Virulence of Entamoeba histolytica

S Munguía-Robledo, E Orozco, G García-Rivera… - Pathogens, 2023 - mdpi.com
Lysine methylation, a posttranslational modification catalyzed by protein lysine
methyltransferases (PKMTs), is involved in epigenetics and several signaling pathways …