PGC-1 coactivators: inducible regulators of energy metabolism in health and disease

BN Finck, DP Kelly - The Journal of clinical investigation, 2006 - Am Soc Clin Investig
Members of the PPARγ coactivator-1 (PGC-1) family of transcriptional coactivators serve as
inducible coregulators of nuclear receptors in the control of cellular energy metabolic …

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases

L Qian, Y Zhu, C Deng, Z Liang, J Chen… - … and Targeted Therapy, 2024 - nature.com
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s),
consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related …

Do PPARGC1A and PPARα polymorphisms influence sprint or endurance phenotypes?

N Eynon, Y Meckel, M Sagiv, C Yamin… - … journal of medicine …, 2010 - Wiley Online Library
Functional Gly482Ser (rs8192678) and G/C (rs4253778) polymorphisms in the Peroxisome
proliferator‐activated receptor γ coactivator1 (PPARGC1A) and Peroxisome proliferator …

The PPARGC1Agene Gly482Ser in Polish and Russian athletes

A Maciejewska, M Sawczuk, P Cieszczyk… - Journal of sports …, 2012 - Taylor & Francis
Peroxysome proliferator-activated receptor gamma coactivator-1-alpha (PGC-1α; encoded
by the gene PPARGC1A in humans) is a crucial component in training-induced muscle …

Linking Metabolic Disease With the PGC-1α Gly482Ser Polymorphism

R Vandenbeek, NP Khan, JL Estall - Endocrinology, 2018 - academic.oup.com
Peroxisome proliferator–activated receptor γ coactivator 1-α (PGC-1 α) is a highly conserved
transcriptional coactivator enriched in metabolically active tissues including liver, adipose …

PPARGC1A Variation Associated With DNA Damage, Diabetes, and Cardiovascular Diseases: The Boston Puerto Rican Health Study

CQ Lai, KL Tucker, LD Parnell, X Adiconis… - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—Individuals with type 2 diabetes exhibit higher DNA damage and increased
risk of cardiovascular disease (CVD). However, mechanisms underlying the association …

Development and validation of a RNA binding protein-associated prognostic model for hepatocellular carcinoma

M Wang, F Jiang, K Wei, J Wang… - … in cancer research …, 2021 - journals.sagepub.com
Background: Dysregulation of RNA binding proteins (RBPs) has been identified in multiple
malignant tumors correlated with tumor progression and occurrence. However, the function …

The influence of the differentiation of genes encoding peroxisome proliferator-activated receptors and their coactivators on nutrient and energy metabolism

A Maciejewska-Skrendo, M Massidda, F Tocco… - Nutrients, 2022 - mdpi.com
Genetic components may play an important role in the regulation of nutrient and energy
metabolism. In the presence of specific genetic variants, metabolic dysregulation may occur …

[HTML][HTML] PGC-1 coactivators in β-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids

D Oropeza, N Jouvet, K Bouyakdan, G Perron… - Molecular …, 2015 - Elsevier
Objectives Peroxisome proliferator-activated receptor γ coactivator 1 (PPARGCA1, PGC-1)
transcriptional coactivators control gene programs important for nutrient metabolism. Islets of …

Common polymorphisms of the peroxisome proliferator-activated receptor–γ (Pro12Ala) and peroxisome proliferator-activated receptor–γ coactivator–1 (Gly482Ser) …

MC Hsieh, KD Lin, KJ Tien, ST Tu, JY Hsiao, SJ Chang… - Metabolism, 2010 - Elsevier
We investigated the effects of the common polymorphisms in the peroxisome proliferator-
activated receptor–γ (PPAR-γ; Pro12Ala) and in PPAR-γ coactivator–1 (PGC-1; Gly482Ser) …