[HTML][HTML] Pregnancy-related maternal physiological adaptations and fetal chemical exposure

MT Vinnars, M Bixo, P Damdimopoulou - Molecular and Cellular …, 2023 - Elsevier
Prenatal life represents a susceptible window of development during which chemical
exposures can permanently alter fetal development, leading to an increased likelihood of …

Non‐Viral RNA Delivery During Pregnancy: Opportunities and Challenges

N Chaudhary, AN Newby, KA Whitehead - Small, 2023 - Wiley Online Library
During pregnancy, the risk of maternal and fetal adversities increases due to physiological
changes, genetic predispositions, environmental factors, and infections. Unfortunately …

Young-onset breast cancer outcomes by time since recent childbirth in Utah

Z Zhang, S Bassale, S Jindal, A Fraser… - JAMA Network …, 2022 - jamanetwork.com
Importance Breast cancer diagnosed within 5 to 10 years after childbirth, calledpostpartum
breast cancer (PPBC), is associated with increased risk for metastasis and death. Whether a …

Spatial-temporal proliferation of hepatocytes during pregnancy revealed by genetic lineage tracing

S He, Z Guo, M Zhou, H Wang, Z Zhang, M Shi, X Li… - Cell Stem Cell, 2023 - cell.com
The maternal liver undergoes dramatic enlargement to adapt to the increased metabolic
demands during pregnancy. However, the cellular sources for liver growth during pregnancy …

Maternal hepatic adaptations during obese pregnancy encompass lobe-specific mitochondrial alterations and oxidative stress

LF Grilo, JD Martins, MS Diniz, C Tocantins… - Clinical …, 2023 - portlandpress.com
Maternal obesity (MO) is rising worldwide, affecting half of all gestations, constituting a
possible risk-factor for some pregnancy-associated liver diseases (PALD) and hepatic …

Adipose tissue-liver cross-talk: a route to hepatic dysfunction in pregnant women with obesity

D Sousa, CC Magalhães, P Matafome… - Bioscience …, 2024 - portlandpress.com
Obesity during pregnancy has been escalating, becoming a huge problem that poses
consequences not only for the health of the offspring but also for the maternal well-being …

A multi-tissue metabolome atlas of primate pregnancy

D Yu, H Wan, C Tong, L Guang, G Chen, J Su, L Zhang… - Cell, 2024 - cell.com
Pregnancy induces dramatic metabolic changes in females; yet, the intricacies of this
metabolic reprogramming remain poorly understood, especially in primates. Using …

Periportal hepatocyte proliferation at midgestation governs maternal glucose homeostasis in mice

S Kozuki, M Kabata, S Sakurai, K Iwaisako… - Communications …, 2023 - nature.com
The maternal liver is challenged by metabolic demands throughout pregnancy. However,
hepatocyte dynamics and their physiological significance in pregnancy remain unclear …

[HTML][HTML] The Inhibitory Effect of Geraniol on CCL4-induced Hepatorenal Toxicity in Pregnant Mice through the PI3K/AKT Signaling Pathway

SA Alzahrani, GM Bekhet, RB Ammar… - Saudi Journal of …, 2024 - journals.lww.com
Background: Hepatotoxicity caused by CCL 4 is well known. Geraniol (GNL) has high
antioxidant effect that can induces liver regeneration. However, the protective effect of GNL …

Pregnancy-induced metabolic reprogramming and regenerative responses to pro-aging stresses

D Yu, L Luo, H Wang, N Shyh-Chang - Trends in Endocrinology & …, 2024 - cell.com
Pregnancy is associated with physiological adaptations that affect virtually all organs,
enabling the mother to support the growing fetus and placenta while withstanding the …