Chronic wounds

V Falanga, RR Isseroff, AM Soulika… - Nature Reviews …, 2022 - nature.com
Chronic wounds are characterized by their inability to heal within an expected time frame
and have emerged as an increasingly important clinical problem over the past several …

Breakthrough treatments for accelerated wound healing

BR Freedman, C Hwang, S Talbot, B Hibler… - Science …, 2023 - science.org
Skin injuries across the body continue to disrupt everyday life for millions of patients and
result in prolonged hospital stays, infection, and death. Advances in wound healing devices …

Osteoimmunity‐regulating biomimetically hierarchical scaffold for augmented bone regeneration

J Zhang, D Tong, H Song, R Ruan, Y Sun… - Advanced …, 2022 - Wiley Online Library
Engineering a proper immune response following biomaterial implantation is essential to
bone tissue regeneration. Herein, a biomimetically hierarchical scaffold composed of …

The role of oxidative stress and antioxidants in diabetic wound healing

L Deng, C Du, P Song, T Chen, S Rui… - Oxidative medicine …, 2021 - Wiley Online Library
Foot ulcers are one of the most common and severe complication of diabetes mellitus with
significant resultant morbidity and mortality. Multiple factors impair wound healing include …

[HTML][HTML] Deferoxamine B: a natural, excellent and versatile metal chelator

D Bellotti, M Remelli - Molecules, 2021 - mdpi.com
Deferoxamine B is an outstanding molecule which has been widely studied in the past
decade for its ability to bind iron and many other metal ions. The versatility of this metal …

[HTML][HTML] Electrospun nanofibers/nanofibrous scaffolds loaded with silver nanoparticles as effective antibacterial wound dressing materials

S Alven, B Buyana, Z Feketshane, BA Aderibigbe - Pharmaceutics, 2021 - mdpi.com
The treatment of wounds is expensive and challenging. Most of the available wound
dressings are not effective and suffer from limitations such as poor antimicrobial activity …

Calcium ion cross-linked sodium alginate hydrogels containing deferoxamine and copper nanoparticles for diabetic wound healing

S Li, X Wang, J Chen, J Guo, M Yuan, G Wan… - International Journal of …, 2022 - Elsevier
Chronic non-healing diabetic wounds and ulcers can be fatal, lead to amputations, and
remain a major challenge to medical, and health care sectors. Susceptibility to infection and …

Oriented nanofibrous P (MMD-co-LA)/Deferoxamine nerve scaffold facilitates peripheral nerve regeneration by regulating macrophage phenotype and …

X Dong, P Wu, L Yan, K Liu, W Wei, Q Cheng, X Liang… - Biomaterials, 2022 - Elsevier
Delayed injured nerve regeneration remains a clinical problem, partly ascribing to the lack of
regulation of regenerative microenvironment, topographical cues, and blood nourishment …

Challenges and opportunities of deferoxamine delivery for treatment of Alzheimer's disease, Parkinson's disease, and intracerebral hemorrhage

AC Farr, MP Xiong - Molecular pharmaceutics, 2020 - ACS Publications
Deferoxamine mesylate (DFO) is an FDA-approved, hexadentate iron chelator routinely
used to alleviate systemic iron burden in thalassemia major and sickle cell patients. Iron …

Autophagosomes Defeat Ferroptosis by Decreasing Generation and Increasing Discharge of Free Fe2+ in Skin Repair Cells to Accelerate Diabetic Wound Healing

S Cui, X Liu, Y Liu, W Hu, K Ma, Q Huang… - Advanced …, 2023 - Wiley Online Library
Ferroptosis plays an essential role in the development of diabetes and its complications,
suggesting potential therapeutic strategies targeting ferroptosis. Secretory autophagosomes …