Nucleotide excision repair leaves a mark on chromatin: DNA damage detection in nucleosomes
K Apelt, H Lans, OD Schärer… - Cellular and Molecular Life …, 2021 - Springer
Global genome nucleotide excision repair (GG-NER) eliminates a broad spectrum of DNA
lesions from genomic DNA. Genomic DNA is tightly wrapped around histones creating a …
lesions from genomic DNA. Genomic DNA is tightly wrapped around histones creating a …
Mechanism and regulation of DNA damage recognition in mammalian nucleotide excision repair
K Sugasawa - The Enzymes, 2019 - Elsevier
Nucleotide excision repair (NER) is a versatile DNA repair pathway that eliminates various
helix-distorting base lesions such as ultraviolet (UV)-induced photolesions. Several …
helix-distorting base lesions such as ultraviolet (UV)-induced photolesions. Several …
Single-molecule visualization reveals the damage search mechanism for the human NER protein XPC-RAD23B
DNA repair is critical for maintaining genomic integrity. Finding DNA lesions initiates the
entire repair process. In human nucleotide excision repair (NER), XPC-RAD23B recognizes …
entire repair process. In human nucleotide excision repair (NER), XPC-RAD23B recognizes …
Structure and mechanism of pyrimidine–pyrimidone (6-4) photoproduct recognition by the Rad4/XPC nucleotide excision repair complex
Failure in repairing ultraviolet radiation-induced DNA damage can lead to mutations and
cancer. Among UV-lesions, the pyrimidine–pyrimidone (6-4) photoproduct (6-4PP) is …
cancer. Among UV-lesions, the pyrimidine–pyrimidone (6-4) photoproduct (6-4PP) is …
Differing structures and dynamics of two photolesions portray verification differences by the human XPD helicase
I Fu, NE Geacintov, S Broyde - Nucleic acids research, 2023 - academic.oup.com
Ultraviolet light generates cyclobutane pyrimidine dimer (CPD) and pyrimidine 6− 4
pyrimidone (6− 4PP) photoproducts that cause skin malignancies if not repaired by …
pyrimidone (6− 4PP) photoproducts that cause skin malignancies if not repaired by …
Mechanism of lesion verification by the human XPD helicase in nucleotide excision repair
In nucleotide excision repair (NER), the xeroderma pigmentosum D helicase (XPD) scans
DNA searching for bulky lesions, stalls when encountering such damage to verify its …
DNA searching for bulky lesions, stalls when encountering such damage to verify its …
Impact of DNA Adduct Size, Number, and Relative Position on the Toxicity of Aromatic Amines: A Molecular Dynamics Case Study of ANdG- and APdG-Containing …
RW Kung, TK Deak, CA Griffith-Salik… - Journal of Chemical …, 2021 - ACS Publications
Human exposure to aromatic amines (AAs) can result in carcinogenic DNA adducts. To
complement previous work geared toward understanding the mutagenicity of AA-derived …
complement previous work geared toward understanding the mutagenicity of AA-derived …
Tethering-facilitated DNA 'opening'and complementary roles of β-hairpin motifs in the Rad4/XPC DNA damage sensor protein
XPC/Rad4 initiates eukaryotic nucleotide excision repair on structurally diverse helix-
destabilizing/distorting DNA lesions by selectively 'opening'these sites while rapidly diffusing …
destabilizing/distorting DNA lesions by selectively 'opening'these sites while rapidly diffusing …
Sequence specificity, energetics and mechanism of mismatch recognition by DNA damage sensing protein Rad4/XPC
The ultraviolet (UV) radiation-induced DNA lesions play a causal role in many prevalent
genetic skin-related diseases and cancers. The damage sensing protein Rad4/XPC …
genetic skin-related diseases and cancers. The damage sensing protein Rad4/XPC …
Impact of DNA sequences on DNA 'opening'by the Rad4/XPC nucleotide excision repair complex
Rad4/XPC recognizes diverse DNA lesions to initiate nucleotide excision repair (NER).
However, NER propensities among lesions vary widely and repair-resistant lesions are …
However, NER propensities among lesions vary widely and repair-resistant lesions are …