Recent progress in understanding the molecular basis of cellular processes, identification of
promising therapeutic targets and evolution of the regulatory landscape makes this an …

Chronic lymphocytic leukemia (CLL) is an incurable B-cell neoplasm characterized by highly
variable clinical outcomes. In recent years, genomic and molecular studies revealed a …

Metastases from cells outside of the central nervous system are the most common cancer
found in the brain and are commonly associated with poor prognosis. Although cancer …

In human cells BRAF oncogene is invariably expressed as a mix of two coding transcripts:
BRAF-ref and BRAF-X1. These two mRNA isoforms, remarkably different in the sequence …

Overactivation of the mitogen‐activated protein kinase (MAPK) pathway is an important
driver of many human cancers. First line, FDA‐approved therapies targeting MAPK …

The presence of BRAF variant V595E, as well as an increased cyclooxygenase-2 (COX-2)
expression in canine transitional cell carcinoma (TCC) are well-described in the literature …

ABSTRACT BRAF is one of multiple RAF proteins responsible for the activation of the MAPK
cell signalling cascade involved in cell growth, differentiation, and survival. A hotspot …

BRAFV600E comes as two main splicing variants. The well-studied ref isoform and the
recently discovered X1 isoform are co-expressed in cancer cells and differ in terms of 3'UTR …

Raf protein kinases act as Ras-GTP sensing components of the ERK signal transduction
pathway in animal cells, influencing cell proliferation, differentiation, and survival. In …

Here we present miR-CATCHv2. 0, an implemented experimental method that allows the
identification of the microRNA species directly bound to an RNA of interest. After cross …