The heme peroxidase family generates a battery of oxidants both for synthetic purposes, and
in the innate immune defence against pathogens. Myeloperoxidase (MPO) is the most …

Reactive oxygen species (ROS), initially categorized as toxic by-products of aerobic
metabolism, have often been called a double-edged sword. ROS are considered …

A marked increase in interest has occurred over the last few years in the role that
mammalian heme peroxidase enzymes, primarily myeloperoxidase, eosinophil peroxidase …

Submucosal glands contribute to airway surface liquid (ASL), a film that protects all airway
surfaces. Glandular mucus comprises electrolytes, water, the gel-forming mucin MUC5B …

The importance of reactive oxygen species (ROS) in innate immunity was first recognized in
professional phagocytes undergoing a 'respiratory burst'upon activation. This robust oxygen …

Lactoperoxidase (LPO) is an enzyme with antimicrobial properties present in saliva, milk,
tears, and airway secretions. Although the formation of microbicidal oxidants by LPO has …

Heme peroxidases are a major source of reactive oxidants at sites of inflammation in
biological systems. The formation of some of these oxidants (eg hypochlorous acid, HOCl) is …

The natural antimicrobial system present in milk, the lactoperoxidase (LP) system, has been
used to preserve raw milk quality in areas where it is not possible to use mechanical …

Airway disease currently causes most of the morbidity and mortality in patients with cystic
fibrosis (CF). However, understanding the pathogenesis of CF lung disease and developing …

Rationale: The respiratory tract is constantly exposed to airborne microorganisms.
Nevertheless, normal airways remain sterile without recruiting phagocytes. This innate …