Stem cell-based embryo models open an unprecedented avenue for modeling
embryogenesis, cell lineage differentiation, tissue morphogenesis, and organogenesis in …

Dramatic nuclear reorganization occurs during early development to convert terminally
differentiated gametes to a totipotent zygote, which then gives rise to an embryo. Aberrant …

Organoids are lumen‐containing multicellular structures that recapitulate key features of the
organs, and are increasingly used in models of disease, drug testing, and regenerative …

Recent advances in methods to culture pluripotent stem cells to model human development
have resulted in entities that increasingly have recapitulated advanced stages of early …

Pharmaceuticals intended for use in patients of childbearing potential need to be tested for
teratogenicity before marketing. Several pharmaceutical companies use animal-free in vitro …

During embryogenesis, organisms acquire their shape given boundary conditions that
impose geometrical, mechanical and biochemical constraints. A detailed integrative …

Hippo effectors YAP and TAZ control cell fate and survival through various mechanisms,
including transcriptional regulation of key genes. However, much of this research has been …

Minimal in vitro systems composed of embryonic stem cells (ESCs) have been shown to
recapitulate the establishment of the anteroposterior (AP) axis. In contrast to the native …

Cardiac congenital disabilities are the most common organ malformations, but we still do not
understand how they arise in the human embryo. Moreover, although cardiovascular …

Post-implantation embryo development commences with a bilaminar disc in most mammals,
including humans. Whereas access to early human embryos is limited and subject to greater …