Osteoarthritis (OA) is a progressive chronic inflammation that leads to cartilage
degeneration. OA Patients are commonly given pharmacological treatment, but the available …

Highlights•We categorize the challenges and corresponding solutions for nano-drug
delivery in OA.•We summarize the design and advantages of recent nano-drug delivery …

The complexity of CRISPR machinery is a challenge to its application for nonviral in vivo
therapeutic gene editing. Here, we demonstrate that proteins, regardless of size or charge …

Radiotherapy-resistant glioblastoma (rrGBM) remains a significant clinical challenge
because of high infiltrative growth characterized by activation of antiapoptotic signal …

With the change in lifestyle and aging of the population, osteoarthritis (OA) is emerging as a
major medical burden globally. OA is a chronic inflammatory and degenerative disease …

Osteoarthritis (OA) is a degenerative musculoskeletal disorder affecting the whole synovial
joint and globally impacts more than one in five individuals aged 40 and over, representing …

Osteoarthritis (OA) is a multifactorial disease that affects the entire joint, often resulting in
severe pain, disability, psychological distress, and a lower quality of life. Patient self …

Osteoarthritis (OA) represents an enduring and widespread global burden, causing
significant morbidity and disability, whose pathology is characterized by persistent …

Osteoarthritis (OA) is a chronic, debilitating disease that substantially impairs the quality of
life of affected individuals. The underlying mechanisms of OA are diverse and are becoming …

MicroRNAs play a crucial role in regulating cartilage extracellular matrix (ECM) metabolism
and are being explored as potential therapeutic targets for osteoarthritis (OA). The present …