Intra-articular drug delivery systems for osteoarthritis therapy: Shifting from sustained release to enhancing penetration into cartilage
H Huang, Z Lou, S Zheng, J Wu, Q Yao, R Chen… - Drug …, 2022 - Taylor & Francis
Osteoarthritis (OA) is a progressive chronic inflammation that leads to cartilage
degeneration. OA Patients are commonly given pharmacological treatment, but the available …
degeneration. OA Patients are commonly given pharmacological treatment, but the available …
Intra-articular nanodrug delivery strategies for treating osteoarthritis
D Zhou, F Zhou, S Sheng, Y Wei, X Chen, J Su - Drug Discovery Today, 2023 - Elsevier
Highlights•We categorize the challenges and corresponding solutions for nano-drug
delivery in OA.•We summarize the design and advantages of recent nano-drug delivery …
delivery in OA.•We summarize the design and advantages of recent nano-drug delivery …
Nonviral In Vivo Delivery of CRISPR-Cas9 Using Protein-Agnostic, High-Loading Porous Silicon and Polymer Nanoparticles
RB Fletcher, LD Stokes, IB Kelly III, KM Henderson… - ACS …, 2023 - ACS Publications
The complexity of CRISPR machinery is a challenge to its application for nonviral in vivo
therapeutic gene editing. Here, we demonstrate that proteins, regardless of size or charge …
therapeutic gene editing. Here, we demonstrate that proteins, regardless of size or charge …
Radiation-triggered selenium-engineered mesoporous silica nanocapsules for RNAi therapy in radiotherapy-resistant glioblastoma
X Tang, Z Wang, Y Xie, Y Liu, K Yang, T Li, H Shen… - ACS …, 2023 - ACS Publications
Radiotherapy-resistant glioblastoma (rrGBM) remains a significant clinical challenge
because of high infiltrative growth characterized by activation of antiapoptotic signal …
because of high infiltrative growth characterized by activation of antiapoptotic signal …
Management of osteoarthritis: From drug molecules to nano/micromedicines
M Di Francesco, A Fragassi… - Wiley …, 2022 - Wiley Online Library
With the change in lifestyle and aging of the population, osteoarthritis (OA) is emerging as a
major medical burden globally. OA is a chronic inflammatory and degenerative disease …
major medical burden globally. OA is a chronic inflammatory and degenerative disease …
Polymeric nanoparticles for drug delivery in osteoarthritis
AP Pontes, TJM Welting, J Rip, LB Creemers - Pharmaceutics, 2022 - mdpi.com
Osteoarthritis (OA) is a degenerative musculoskeletal disorder affecting the whole synovial
joint and globally impacts more than one in five individuals aged 40 and over, representing …
joint and globally impacts more than one in five individuals aged 40 and over, representing …
Therapeutic potential of nanotechnology-based approaches in osteoarthritis
L Xiao, J Cui, Z Sun, Y Liu, J Zheng… - Frontiers in …, 2022 - frontiersin.org
Osteoarthritis (OA) is a multifactorial disease that affects the entire joint, often resulting in
severe pain, disability, psychological distress, and a lower quality of life. Patient self …
severe pain, disability, psychological distress, and a lower quality of life. Patient self …
[HTML][HTML] Microenvironment-Responsive Nanosystems for Osteoarthritis Therapy
S Li, Y Xiong, H Zhu, T Ma, X Sun, J Xiao - Engineered Regeneration, 2023 - Elsevier
Osteoarthritis (OA) represents an enduring and widespread global burden, causing
significant morbidity and disability, whose pathology is characterized by persistent …
significant morbidity and disability, whose pathology is characterized by persistent …
Engineering approaches for RNA-based and cell-based osteoarthritis therapies
Osteoarthritis (OA) is a chronic, debilitating disease that substantially impairs the quality of
life of affected individuals. The underlying mechanisms of OA are diverse and are becoming …
life of affected individuals. The underlying mechanisms of OA are diverse and are becoming …
MicroRNA-224-5p nanoparticles balance homeostasis via inhibiting cartilage degeneration and synovial inflammation for synergistic alleviation of osteoarthritis
H Chen, F Chen, F Hu, Y Li, M Zhang, Q Zhou, T Ding… - Acta Biomaterialia, 2023 - Elsevier
MicroRNAs play a crucial role in regulating cartilage extracellular matrix (ECM) metabolism
and are being explored as potential therapeutic targets for osteoarthritis (OA). The present …
and are being explored as potential therapeutic targets for osteoarthritis (OA). The present …