The membrane proteins CD38 and CD157 belong to an evolutionarily conserved family of
enzymes that play crucial roles in human physiology. Expressed in distinct patterns in most …

Classically (M1) and alternatively activated (M2) macrophages exhibit distinct phenotypes
and functions. It has been difficult to dissect macrophage phenotypes in vivo, where a …

Macrophages and their monocyte precursors mediate innate immune responses and can
promote a spectrum of phenotypes from pro-inflammatory to pro-resolving. Currently, there …

CD38 is a multifunctional protein widely expressed in cells from the immune system and as
a soluble form in biological fluids. CD38 expression is up-regulated by an array of …

The formyl peptide receptor (FPR) family is involved in host defence against pathogens, but
also in sensing internal molecules that may constitute signals of cellular dysfunction. It …

The transient potential receptor melastatin‐2 (TRPM2) channel has emerged as an
important Ca2+ signalling mechanism in a variety of cells, contributing to cellular functions …

Store‐operated Ca2+ entry (SOCE) is a mechanism used by many cells types including
lymphocytes and other immune cells to increase intracellular Ca2+ concentrations to initiate …

Myeloid-derived suppressor cells (MDSC) are an immunosuppressive population of
immature myeloid cells found in advanced-stage cancer patients and mouse tumor models …

Neutrophil granulocytes traffic into sites of organ injury in which they may not only participate
in tissue repair and pathogen clearance but may also contribute to collateral cell damage …

Proper recruitment and activation of neutrophils to/at sites of infection/inflammation relies
largely on the surface expression of chemoattractant receptors of which a formyl peptide …