Single-cell image analysis provides a powerful approach for studying cell-to-cell
heterogeneity, which is an important attribute of isogenic cell populations, from microbial …

Cells are inherently dynamic, whether they are responding to environmental conditions or
simply at equilibrium, with biomolecules constantly being made and destroyed. Due to their …

Aging is associated with progressive phenotypic changes. Virtually all cellular phenotypes
are produced by proteins, and their structural alterations can lead to age-related diseases …

Our ability to understand the genotype‐to‐phenotype relationship is hindered by the lack of
detailed understanding of phenotypes at a single‐cell level. To systematically assess cell‐to …

The use of stem cells is part of a strategy for the treatment of a large number of diseases.
However, the source of the original stem cells for use is extremely important and determines …

Phenotypic plasticity, the ability of an organism to display different phenotypes across
environments, is widespread in nature. Plasticity aids survival in novel environments …

Marine organisms have received mounting attention in antiaging activity due to their
exclusive chemicals. This review aims at revealing and discussing prospective antiaging …

Individual cells within a clonal population can display pronounced phenotypic differences. In
multicellular organisms, such differentiation is controlled by numerous microenvironmental …

In 1999 VP Skulachev proposed the term “mitoptosis” to refer to the programmed elimination
of mitochondria in living cells. According to the initial thought, mitoptosis serves to protect …

Replicative senescence, which is induced by telomere shortening, underlies the loss of
regeneration capacity of organs and is ultimately detrimental to the organism. At the same …