[HTML][HTML] β-Lactamases and β-Lactamase Inhibitors in the 21st Century
The β-lactams retain a central place in the antibacterial armamentarium. In Gram-negative
bacteria, β-lactamase enzymes that hydrolyze the amide bond of the four-membered β …
bacteria, β-lactamase enzymes that hydrolyze the amide bond of the four-membered β …
From theory to practice: translating whole-genome sequencing (WGS) into the clinic
Hospitals worldwide are facing an increasing incidence of hard-to-treat infections. Limiting
infections and providing patients with optimal drug regimens require timely strain …
infections and providing patients with optimal drug regimens require timely strain …
Tetracycline-inactivating enzymes
JL Markley, TA Wencewicz - Frontiers in microbiology, 2018 - frontiersin.org
Tetracyclines have been foundational antibacterial agents for more than 70 years. Renewed
interest in tetracycline antibiotics is being driven by advancements in tetracycline synthesis …
interest in tetracycline antibiotics is being driven by advancements in tetracycline synthesis …
Class C β-lactamases: molecular characteristics
Class C β-lactamases or cephalosporinases can be classified into two functional groups (1,
1e) with considerable molecular variability (≤ 20% sequence identity). These enzymes are …
1e) with considerable molecular variability (≤ 20% sequence identity). These enzymes are …
Genetic basis of molecular mechanisms in β-lactam resistant gram-negative bacteria
Antibiotic-resistant bacteria are considered one of the major global threats to human and
animal health. The most harmful among the resistant bacteria are β-lactamase producing …
animal health. The most harmful among the resistant bacteria are β-lactamase producing …
Genomic plasticity associated with antimicrobial resistance in Vibrio cholerae
The Bay of Bengal is known as the epicenter for seeding several devastating cholera
outbreaks across the globe. Vibrio cholerae, the etiological agent of cholera, has …
outbreaks across the globe. Vibrio cholerae, the etiological agent of cholera, has …
Environmental superbugs: The case study of Pedobacter spp.
The environment is one of the main reservoirs of antibiotic resistance genes (ARGs) but
multidrug resistant (MDR) environmental isolates are barely characterised. As suggested by …
multidrug resistant (MDR) environmental isolates are barely characterised. As suggested by …
Antibiotic resistance genes in the Actinobacteria phylum
M Fatahi-Bafghi - European Journal of Clinical Microbiology & Infectious …, 2019 - Springer
The Actinobacteria phylum is one of the oldest bacterial phyla that have a significant role in
medicine and biotechnology. There are a lot of genera in this phylum that are causing …
medicine and biotechnology. There are a lot of genera in this phylum that are causing …
Drug resistance: An incessant fight against evolutionary strategies of survival
F Ramos-Martín, N D'amelio - Microbiology Research, 2023 - mdpi.com
The inherent capacity of all organisms to evolve under selective pressure has created
multidrug-resistant microbes and cells that are now threatening decades of progress in …
multidrug-resistant microbes and cells that are now threatening decades of progress in …
Mechanism of drug resistance in bacteria: efflux pump modulation for designing of new antibiotic enhancers
H Mohanty, S Pachpute, RP Yadav - Folia Microbiologica, 2021 - Springer
Drug resistance has now become a serious concern in the domain of microbial infection.
Bacteria are becoming smarter by displaying a variety of mechanisms during drug …
Bacteria are becoming smarter by displaying a variety of mechanisms during drug …