The β-lactams retain a central place in the antibacterial armamentarium. In Gram-negative
bacteria, β-lactamase enzymes that hydrolyze the amide bond of the four-membered β …

Hospitals worldwide are facing an increasing incidence of hard-to-treat infections. Limiting
infections and providing patients with optimal drug regimens require timely strain …

Tetracyclines have been foundational antibacterial agents for more than 70 years. Renewed
interest in tetracycline antibiotics is being driven by advancements in tetracycline synthesis …

Class C β-lactamases or cephalosporinases can be classified into two functional groups (1,
1e) with considerable molecular variability (≤ 20% sequence identity). These enzymes are …

Antibiotic-resistant bacteria are considered one of the major global threats to human and
animal health. The most harmful among the resistant bacteria are β-lactamase producing …

The Bay of Bengal is known as the epicenter for seeding several devastating cholera
outbreaks across the globe. Vibrio cholerae, the etiological agent of cholera, has …

The environment is one of the main reservoirs of antibiotic resistance genes (ARGs) but
multidrug resistant (MDR) environmental isolates are barely characterised. As suggested by …

The Actinobacteria phylum is one of the oldest bacterial phyla that have a significant role in
medicine and biotechnology. There are a lot of genera in this phylum that are causing …

The inherent capacity of all organisms to evolve under selective pressure has created
multidrug-resistant microbes and cells that are now threatening decades of progress in …

Drug resistance has now become a serious concern in the domain of microbial infection.
Bacteria are becoming smarter by displaying a variety of mechanisms during drug …