Neutrophils promptly accumulate in large numbers at sites of tissue injury. Injuries to the skin
or mucosae disrupt barriers against the external environment, and the bactericidal actions of …

Specialized pro-resolving mediators (SPMs) are enzymatically derived from essential fatty
acids and have important roles in orchestrating the resolution of tissue inflammation—that is …

Polymorphonuclear leukocytes or neutrophils play a critical role in the maintenance of
intestinal homeostasis. They have elegant defense mechanisms to eliminate microbes that …

▪ Abstract Macrophages express a broad range of plasma membrane receptors that mediate
their interactions with natural and altered-self components of the host as well as a range of …

The complement cascade is an ancient immune‐surveillance system that not only provides
protection from pathogen invasion but has also evolved to participate in physiological …

We recently uncovered two new families of potent docosahexaenoic acid-derived mediators,
termed D series resolvins (Rv; resolution phase interaction products) and protectins. Here …

The primary function of neutrophils in host defense is to contain and eradicate invading
microbial pathogens. This is achieved through a series of swift and highly coordinated …

Migration of neutrophils (PMN) across epithelia is a pathological hallmark of numerous
muco‐sal diseases. Whereas lesions at mucosal surfaces are generally self‐limiting …

The inflammatory bowel diseases (IBDs; Crohn's disease, and ulcerative colitis) are
chronically relapsing inflammatory disorders of the intestine and/or colon. The precise …

Resolvin-E1 (RvE1) has been demonstrated to promote inflammatory resolution in
numerous disease models. Given the importance of epithelial cells to coordination of …