Discovery of acetohydroxyacid synthase inhibitors as anti-tuberculosis lead compounds from natural products
Y Niu, Z Wu, Q Hu, Y Wu, Q Jiang, X Yang - Bioorganic & Medicinal …, 2025 - Elsevier
Acetohydroxy acid synthase (AHAS) is a key enzyme that catalyzes the synthesis of
branched-chain amino acids, which is indispensable for the survival and growth of …
branched-chain amino acids, which is indispensable for the survival and growth of …
The exceptions that prove the rule—a historical view of bedaquiline susceptibility
In the accompanying study, Nimmo and colleagues estimated the dates of emergence of
mutations in mmpR5 (Rv0678), the most important resistance gene to the anti-tuberculosis …
mutations in mmpR5 (Rv0678), the most important resistance gene to the anti-tuberculosis …
The kinetics of bedaquiline diffusion in tuberculous cavities opens a window for emergence of resistance.
Cavitary tuberculosis (TB) is difficult to cure and a site of relapse. Bedaquiline has been a
wonder drug in the treatment of multidrug resistant TB, but emergence of resistance …
wonder drug in the treatment of multidrug resistant TB, but emergence of resistance …
Careful classification of potential bedaquiline resistance mutations is critical when analysing their clinical impact
Alliance (New York, NY, USA), and the WHO Regional Office for Europe (Copenhagen,
Denmark). CUK's consulting for Becton Dickinson involves a collaboration with Janssen …
Denmark). CUK's consulting for Becton Dickinson involves a collaboration with Janssen …