Polyphenols and visual health: potential effects on degenerative retinal diseases
P Fernandez-Gonzalez, A Mas-Sanchez, P Garriga - Molecules, 2021 - mdpi.com
Dietary polyphenols are a group of natural compounds that have been proposed to have
beneficial effects on human health. They were first known for their antioxidant properties, but …
beneficial effects on human health. They were first known for their antioxidant properties, but …
The retinoid and non-retinoid ligands of the rod visual G protein-coupled receptor
JT Ortega, B Jastrzebska - International Journal of Molecular Sciences, 2019 - mdpi.com
G protein-coupled receptors (GPCRs) play a predominant role in the drug discovery effort.
These cell surface receptors are activated by a variety of specific ligands that bind to the …
These cell surface receptors are activated by a variety of specific ligands that bind to the …
Mice lacking the systemic vitamin a receptor rbpr2 show decreased ocular retinoids and loss of visual function
R Radhakrishnan, M Leung, H Roehrich… - Nutrients, 2022 - mdpi.com
Simple Summary This work represents an initial evaluation of the second RBP4-vitamin A
receptor RBPR2 in a mammalian model. We provide evidence that the membrane localized …
receptor RBPR2 in a mammalian model. We provide evidence that the membrane localized …
Protective effects of flavonoids in acute models of light-induced retinal degeneration
Degeneration of photoreceptors caused by excessive illumination, inherited mutations, or
aging is the principal pathology of blinding diseases. Pharmacological compounds that …
aging is the principal pathology of blinding diseases. Pharmacological compounds that …
Flavonoids improve the stability and function of P23H rhodopsin slowing down the progression of retinitis pigmentosa in mice
The balanced homeostasis of the G protein–coupled receptor (GPCR), rhodopsin (Rho), is
required for vision. Misfolding mutations in Rho cause photoreceptor death, leading to …
required for vision. Misfolding mutations in Rho cause photoreceptor death, leading to …
Flavonoids enhance rod opsin stability, folding, and self-association by directly binding to ligand-free opsin and modulating its conformation
Rhodopsin (Rho) is a visual G protein–coupled receptor expressed in the rod
photoreceptors of the eye, where it mediates transmission of a light signal into a cell and …
photoreceptors of the eye, where it mediates transmission of a light signal into a cell and …
The vitamin A transporter STRA6 adjusts the stoichiometry of chromophore and opsins in visual pigment synthesis and recycling
S Ramkumar, VM Parmar, I Samuels… - Human molecular …, 2022 - academic.oup.com
The retinal pigment epithelium of the vertebrate eyes acquires vitamin A from circulating
retinol binding protein for chromophore biosynthesis. The chromophore covalently links with …
retinol binding protein for chromophore biosynthesis. The chromophore covalently links with …
[HTML][HTML] Galanin receptor 3− A new pharmacological target in retina degeneration
The neuropeptide galanin receptor 3 (GALR3) is a class AG protein-coupled receptor
(GPCR) broadly expressed in the nervous system, including the retina. GALR3 is involved in …
(GPCR) broadly expressed in the nervous system, including the retina. GALR3 is involved in …
Development of novel cytoprotective small compounds inhibiting mitochondria-dependent cell death
We identified cytoprotective small molecules (CSMs) by a cell-based high-throughput
screening of Bax inhibitors. Through a medicinal chemistry program, M109S was developed …
screening of Bax inhibitors. Through a medicinal chemistry program, M109S was developed …
Retinoid analogs and polyphenols as potential therapeutics for age-related macular degeneration
Progressive retinal degeneration manifesting as age-related macular degeneration (AMD) in
the elderly affects millions of individuals worldwide. Among various blinding diseases, AMD …
the elderly affects millions of individuals worldwide. Among various blinding diseases, AMD …