Design, in silico studies and biological evaluation of novel chalcones tethered triazolo[3,4-a]isoquinoline as EGFR inhibitors targeting resistance in non-small cell …
N Abdelaal, MA Ragheb, HM Hassaneen… - Scientific Reports, 2024 - nature.com
A novel series of six [1, 2, 4] triazolo [3, 4-a] isoquinolin-3-yl)-3-(1, 3-diphenyl-1 H-pyrazol-4-
yl) prop-2-en-1-ones (3a–3f) was designed and synthesized. They were characterized …
yl) prop-2-en-1-ones (3a–3f) was designed and synthesized. They were characterized …
Novel diphenyl ether-heterocycles hybrids: Synthesis via Hantzsch and Biginelli reactions, molecular docking simulation, and antimicrobial activities
YA El-Gabry, ME Salem, NS Ibrahim… - Journal of Molecular …, 2024 - Elsevier
By reacting the potassium salt produced by treating 4-hydroxybenzaldehyde with ethanolic
KOH with 4-fluorobenzaldehyde in DMF at reflux, 4, 4′-oxydibenzaldehyde was produced …
KOH with 4-fluorobenzaldehyde in DMF at reflux, 4, 4′-oxydibenzaldehyde was produced …
Molecular docking study, cytotoxicity, cell cycle arrest and apoptotic induction of novel chalcones incorporating thiadiazolyl isoquinoline in cervical cancer
Background: Chalcones are naturally occurring compounds found in various plant species
which are widely used for the traditional popular treatments. Chalcones are distinguished …
which are widely used for the traditional popular treatments. Chalcones are distinguished …
Synthesis, cytotoxicity, anti-inflammatory, anti-metastatic and anti-oxidant activities of novel chalcones incorporating 2-phenoxy-N-arylacetamide and thiophene …
Eight Novel chalcones were synthesized and their structures were confirmed by different
spectral tools. All the prepared compounds were subjected to SRB cytotoxic screening …
spectral tools. All the prepared compounds were subjected to SRB cytotoxic screening …
Facile synthesis, structural activity relationship, molecular modeling and in vitro biological evaluation of new urea derivatives with incorporated isoxazole and thiazole …
FM Sroor, AM Abdelmoniem, IA Abdelhamid - ChemistrySelect, 2019 - Wiley Online Library
A new series of isoxazolyl and thiazolyl urea derivatives was synthesized, fully characterized
and evaluated in vitro as anticancer agents. The chemistry involves a facile protocol for the …
and evaluated in vitro as anticancer agents. The chemistry involves a facile protocol for the …
Synthesis of novel bis (spirocyclic-2-oxindole)-tethered 10b-azachrysene or 10a-azaphenanthrene systems via a Hantzsch-like reaction
AM Abdelmoniem, IA Abdelhamid, AHM Elwahy… - Tetrahedron, 2024 - Elsevier
The effective synthesis of bis (spirocyclic-2-oxindole) tethered to 10b-azachrysene or 10a-
azaphenanthrene moieties via the Hantzsch-like reaction of phenylenebis (methylene)) bis …
azaphenanthrene moieties via the Hantzsch-like reaction of phenylenebis (methylene)) bis …
Bis-aldehydes: Versatile precursors for bis-heterocycles
IA Abdelhamid, MR Shaaban, AHM Elwahy - Advances in Heterocyclic …, 2023 - Elsevier
The widest variety of organic molecules, with major uses in industry, biomedicine, and
chemistry, are heterocycles. They can be found as scaffolds in several medications and …
chemistry, are heterocycles. They can be found as scaffolds in several medications and …
Synthesis of novel bis-pyrazole derivatives as antimicrobial agents
ZA Muhammad, F Alshehrei… - Mini Reviews in …, 2019 - ingentaconnect.com
Background: bis-heterocycles especially those containing pyrazole moiety display much
better antibacterial activity than mono heterocycles. Objective: Herein, we synthesised a …
better antibacterial activity than mono heterocycles. Objective: Herein, we synthesised a …
Novel [l,2,4]triazolo[3,4-a]isoquinoline chalcones as new chemotherapeutic agents: Block IAP tyrosine kinase domain and induce both intrinsic and extrinsic …
Two novel chemotherapeutic chalcones were synthesized and their structures were
confirmed by different spectral tools. Theoretical studies such as molecular modeling were …
confirmed by different spectral tools. Theoretical studies such as molecular modeling were …
Novel triazole-nucleoside hybrids as potential antimicrobial agents: Design, synthesis, and molecular docking
Despite decoding many important genes in the formation of microbes, particularly
pathogenic and mutant ones that lead to resistance to a wide range of antibiotics, this opens …
pathogenic and mutant ones that lead to resistance to a wide range of antibiotics, this opens …