Mechanisms and disease consequences of nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …
Non-alcoholic fatty liver disease: causes, diagnosis, cardiometabolic consequences, and treatment strategies
The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide. In
some patients with NAFLD, isolated steatosis can progress to advanced stages with non …
some patients with NAFLD, isolated steatosis can progress to advanced stages with non …
Nonalcoholic fatty liver disease as a nexus of metabolic and hepatic diseases
VT Samuel, GI Shulman - Cell metabolism, 2018 - cell.com
NAFLD is closely linked with hepatic insulin resistance. Accumulation of hepatic
diacylglycerol activates PKC-ε, impairing insulin receptor activation and insulin-stimulated …
diacylglycerol activates PKC-ε, impairing insulin receptor activation and insulin-stimulated …
Lean NAFLD: a distinct entity shaped by differential metabolic adaptation
Conclusions This study demonstrates that E. multilocularis can induce T‐cell exhaustion
through inhibitory receptor TIGIT, and that blocking this checkpoint may reverse the …
through inhibitory receptor TIGIT, and that blocking this checkpoint may reverse the …
Mechanisms of non-alcoholic fatty liver disease in the metabolic syndrome. A narrative review
Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) are two different
entities sharing common clinical and physio-pathological features, with insulin resistance …
entities sharing common clinical and physio-pathological features, with insulin resistance …
[HTML][HTML] Recent advances in lean NAFLD
R Xu, J Pan, W Zhou, G Ji, Y Dang - Biomedicine & Pharmacotherapy, 2022 - Elsevier
As the predominant type of chronic liver disease, the growing prevalence of nonalcoholic
fatty liver disease (NAFLD) has become a concern worldwide. Although obesity plays the …
fatty liver disease (NAFLD) has become a concern worldwide. Although obesity plays the …
[HTML][HTML] Pathogenesis of non-alcoholic fatty liver disease in children and adolescence: From “two hit theory” to “multiple hit model”
YL Fang, H Chen, CL Wang, L Liang - World journal of …, 2018 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) has become the dominant form of chronic liver
disease in children and adolescents with the increasing prevalence of obesity worldwide …
disease in children and adolescents with the increasing prevalence of obesity worldwide …
[PDF][PDF] TM6SF2: A Novel Genetic Player in Nonalcoholic Fatty Liver and Cardiovascular Disease
Transmembrane 6 superfamily member 2 (TM6SF2) is located on chromosome 19 (19p12)
and encodes for a protein of undetermined function. Genetic studies have reported the …
and encodes for a protein of undetermined function. Genetic studies have reported the …
Liver‐specific deletion of mouse Tm6sf2 promotes steatosis, fibrosis, and hepatocellular cancer
EP Newberry, Z Hall, Y Xie, EA Molitor… - …, 2021 - Wiley Online Library
Background and Aims Human transmembrane 6 superfamily 2 (TM6SF2) variant
rs58542926 is associated with NAFLD and HCC. However, conflicting reports in germline …
rs58542926 is associated with NAFLD and HCC. However, conflicting reports in germline …
Inactivation of Tm6sf2, a gene defective in fatty liver disease, impairs lipidation but not secretion of very low density lipoproteins
A missense mutation (E167K) in TM6SF2 (transmembrane 6 superfamily member 2), a
polytopic protein of unknown function, is associated with the full spectrum of fatty liver …
polytopic protein of unknown function, is associated with the full spectrum of fatty liver …