Solvent-assisted preparation of supported lipid bilayers
The supported lipid bilayer (SLB) platform is a popular cell membrane mimic that is utilized
in the chemical, biological, materials science, and medical fields. To date, SLB preparation …
in the chemical, biological, materials science, and medical fields. To date, SLB preparation …
Crystalline Lipid Domains: Characterization by X‐Ray Diffraction and their Relation to Biology
Biological membranes comprise thousands of different lipids, differing in their alkyl chains,
headgroups, and degree of saturation. It is estimated that 5% of the genes in the human …
headgroups, and degree of saturation. It is estimated that 5% of the genes in the human …
Crystalline cholesterol: the material and its assembly lines
N Varsano, J Capua-Shenkar… - Annual review of …, 2022 - annualreviews.org
Cholesterol is an essential component of animal cell membranes because it influences and
controls cell membrane fluidity. Cholesterol is also responsible for the most frequent lethal …
controls cell membrane fluidity. Cholesterol is also responsible for the most frequent lethal …
Development of correlative cryo-soft X-ray tomography and stochastic reconstruction microscopy. A study of cholesterol crystal early formation in cells
N Varsano, T Dadosh, S Kapishnikov… - Journal of the …, 2016 - ACS Publications
We have developed a high resolution correlative method involving cryo-soft X-ray
tomography (cryo-SXT) and stochastic optical reconstruction microscopy (STORM), which …
tomography (cryo-SXT) and stochastic optical reconstruction microscopy (STORM), which …
Formation of cholesterol-rich supported membranes using solvent-assisted lipid self-assembly
This paper describes the application of a solvent-exchange method to prepare supported
membranes containing high fractions of cholesterol (up to∼ 57 mol%) in an apparent …
membranes containing high fractions of cholesterol (up to∼ 57 mol%) in an apparent …
Crystalline domain structure and cholesterol crystal nucleation in single hydrated DPPC: cholesterol: POPC bilayers
Grazing incidence X-ray diffraction measurements were performed on single hydrated
bilayers and monolayers of DPPC: Cholesterol: POPC at varying concentrations. There are …
bilayers and monolayers of DPPC: Cholesterol: POPC at varying concentrations. There are …
Crystallization of cholesterol in phospholipid membranes follows Ostwald's rule of stages
Crystallization of membrane-embedded components within phospholipid bilayers
represents a distinct class of phase transformation that occurs in structurally organized …
represents a distinct class of phase transformation that occurs in structurally organized …
Polymorphism, Structure, and Nucleation of Cholesterol·H2O at Aqueous Interfaces and in Pathological Media: Revisited from a Computational Perspective
M Shepelenko, A Hirsch, N Varsano… - Journal of the …, 2022 - ACS Publications
We revisit the important issues of polymorphism, structure, and nucleation of cholesterol·
H2O using first-principles calculations based on dispersion-augmented density functional …
H2O using first-principles calculations based on dispersion-augmented density functional …
The materials science of pathological crystals
Aberrant crystallization within the human body can lead to several disease states, although
traditionally the pathogenesis of such diseases has not been studied from a materials …
traditionally the pathogenesis of such diseases has not been studied from a materials …
Solubility of cholesterol in lipid membranes and the formation of immiscible cholesterol plaques at high cholesterol concentrations
MA Barrett, S Zheng, LA Toppozini, RJ Alsop, H Dies… - Soft Matter, 2013 - pubs.rsc.org
The molecular in-plane and out-of-plane structure of dimyristoylphosphatidylcholine (DMPC)
membranes containing up to 60 mol% of cholesterol was studied using X-ray diffraction. Up …
membranes containing up to 60 mol% of cholesterol was studied using X-ray diffraction. Up …