The development of mature blood cells of distinct lineages, from the hematopoietic stem
cells (HSCs), involves a progressive restriction of differentiation potential and the …

Transcriptional networks orchestrate complex developmental processes. Such networks are
commonly instigated by master regulators of development. Considerable progress has been …

Blood cell development relies on the expansion and maintenance of haematopoietic stem
and progenitor cells in the embryo. By gene targeting in mouse embryonic stem cells, we …

Hematopoietic stem cells (HSCs) are maintained in a perivascular niche in bone marrow, in
which leptin receptor+(LepR) stromal cells and endothelial cells synthesize factors required …

The zinc-finger transcription factor GATA-2 plays a critical role in maintaining the pool of
early hematopoietic cells. To define its specific functions in the proliferation, survival, and …

The gene coding for the murine transcription factor GATA6 was inactivated by insertion of a
β-galactosidase marker gene. The analysis of heterozygote GATA6/lacZ mice shows two …

The transcription factor GATA-1 is expressed in early hematopoietic progenitors and
specifically down-regulated in myelomonocytic cells during lineage determination. Our …

The discovery of the GATA binding protein (GATA factor) transcription factor family
revolutionized hematology. Studies of GATA proteins have yielded vital contributions to our …

Mouse embryonic stem (ES) cells lacking the transcription factor GATA-1 do not produce
mature red blood cells either in vivo or in vitro. To define the consequences of GATA-1 loss …

The zinc finger transcription factor GATA-1 is essential for erythropoiesis. In its absence,
committed erythroid precursors arrest at the proerythroblast stage of development and …