The role of hypoxia in glioblastoma invasion
AR Monteiro, R Hill, GJ Pilkington, PA Madureira - Cells, 2017 - mdpi.com
Glioblastoma multiforme (GBM), a grade IV astrocytoma, is the most common and deadly
type of primary malignant brain tumor, with a patient's median survival rate ranging from 15 …
type of primary malignant brain tumor, with a patient's median survival rate ranging from 15 …
Regulation of tumor progression by programmed necrosis
SY Lee, MK Ju, HM Jeon, EK Jeong… - Oxidative medicine …, 2018 - Wiley Online Library
Rapidly growing malignant tumors frequently encounter hypoxia and nutrient (eg, glucose)
deprivation, which occurs because of insufficient blood supply. This results in necrotic cell …
deprivation, which occurs because of insufficient blood supply. This results in necrotic cell …
The relationship between tissue factor and cancer progression: insights from bench and bedside
YW van den Berg, S Osanto… - Blood, The Journal …, 2012 - ashpublications.org
It is now widely recognized that a strong correlation exists between cancer and aberrant
hemostasis. Patients with various types of cancers, including pancreatic, colorectal, and …
hemostasis. Patients with various types of cancers, including pancreatic, colorectal, and …
Protease-activated receptor 2 signaling in inflammation
AS Rothmeier, W Ruf - Seminars in immunopathology, 2012 - Springer
Protease-activated receptors (PARs) are G protein-coupled receptors that are activated by
proteolytical cleavage of the amino-terminus and thereby act as sensors for extracellular …
proteolytical cleavage of the amino-terminus and thereby act as sensors for extracellular …
Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2–mediated heparin-binding EGF signaling in endothelial cells
KJ Svensson, P Kucharzewska… - Proceedings of the …, 2011 - National Acad Sciences
Highly malignant tumors, such as glioblastomas, are characterized by hypoxia, endothelial
cell (EC) hyperplasia, and hypercoagulation. However, how these phenomena of the tumor …
cell (EC) hyperplasia, and hypercoagulation. However, how these phenomena of the tumor …
[HTML][HTML] The tumor microenvironment strongly impacts master transcriptional regulators and gene expression class of glioblastoma
The Cancer Genome Atlas (TCGA) project has generated gene expression data that divides
glioblastoma (GBM) into four transcriptional classes: proneural, neural, classical, and …
glioblastoma (GBM) into four transcriptional classes: proneural, neural, classical, and …
Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target
RL Jensen - Journal of neuro-oncology, 2009 - Springer
Hypoxia is implicated in many aspects of tumor development, angiogenesis, and growth in
many different tumors. Brain tumors, particularly the highly aggressive glioblastoma …
many different tumors. Brain tumors, particularly the highly aggressive glioblastoma …
CXCL12 modulation of CXCR4 and CXCR7 activity in human glioblastoma stem-like cells and regulation of the tumor microenvironment
Chemokines are crucial autocrine and paracrine players in tumor development. In particular,
CXCL12, through its receptors CXCR4 and CXCR7, affects tumor progression by controlling …
CXCL12, through its receptors CXCR4 and CXCR7, affects tumor progression by controlling …
The transcription factor Zif268/Egr1, brain plasticity, and memory
The capacity to remember our past experiences and organize our future draws on a number
of cognitive processes that allow our brain to form and store neural representations that can …
of cognitive processes that allow our brain to form and store neural representations that can …
Necrotic reshaping of the glioma microenvironment drives disease progression
Glioblastoma is the most common primary brain tumor and has a dismal prognosis. The
development of central necrosis represents a tipping point in the evolution of these tumors …
development of central necrosis represents a tipping point in the evolution of these tumors …