Dysregulation in lipid metabolism is among the most prominent metabolic alterations in
cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological …

Non-alcoholic fatty liver disease (NAFLD) is a quickly emerging global health problem
representing the most common chronic liver disease in the world. Atherosclerotic …

The heterogeneity of endothelial cells (ECs) across tissues remains incompletely
inventoried. We constructed an atlas of> 32,000 single-EC transcriptomes from 11 mouse …

The mevalonate (MVA) pathway is an essential metabolic pathway that uses acetyl-CoA to
produce sterols and isoprenoids that are integral to tumour growth and progression. In …

Oxysterols are cholesterol metabolites that can be produced through enzymatic or radical
processes. They constitute a large family of lipids (ie the oxysterome) involved in a plethora …

Nonalcoholic fatty liver disease (NAFLD)–induced hepatocellular carcinoma (HCC) is an
emerging malignancy in the developed world; however, mechanisms that contribute to its …

Medicinal plants are essential for improving human health, and around 75% of the
population in developing countries relies mainly on herb-based medicines for health care …

Background Breast cancer (BC) is the second most frequent type of cancer in the world and
most common among women, configuring a major challenge to global health. BC is a …

Cancer is a multifaceted global disease. Transformation of a normal to a malignant cell takes
several steps, including somatic mutations, epigenetic alterations, metabolic reprogramming …

Statins are inhibitors of HMG-CoA reductase, the rate-limiting enzyme of cholesterol
biosynthesis, and have been clinically used to treat cardiovascular disease. However, a …