The morbidity and mortality of autoimmune diseases (Ads) have been increasing worldwide,
and the identification of novel therapeutic strategies for prevention and treatment is urgently …

Mitochondria are a major target in hypoxic/ischemic injury. Mitochondrial impairment
increases with age leading to dysregulation of molecular pathways linked to mitochondria …

Silent information regulator 1 (SIRT1) is a mammalian homolog of the nicotinamide adenine
dinucleotide (NAD)-dependent deacetylase sirtuin family. Sirtuin was originally studied as …

In recent years, epigenetic modifications have been widely researched. As humans age,
environmental and genetic factors may drive inflammation and immune responses by …

Neurodegeneration is a complex neurological phenomenon characterized by disturbed
coherence in neuronal efflux. Progressive neuronal loss and brain damage due to various …

Multiple sclerosis (MS) is an autoimmune inflammatory disorder of the central nervous
system (CNS) resulting in demyelination and axonal loss in the brain and spinal cord. The …

Prescribing a ketogenic diet (KD) is a century-old dietary intervention mainly used in the
context of intractable epilepsy. The classic KD and its variants regained popularity in recent …

Myeloid cells, including parenchymal microglia, perivascular and meningeal macrophages,
and dendritic cells (DCs), are present in the central nervous system (CNS) and establish an …

Clinical trial results demonstrating that B-cell depletion substantially reduces new relapses
in patients with multiple sclerosis (MS) have established that B cells play a role in the …

Aims Oxidative stress plays a crucial role in the pathogenesis of multiple sclerosis (MS).
Melatonin has a central role in the modulation of oxidative stress pathways. We aimed to …