Chronic pain is a common, complex, and distressing problem that has a profound impact on
individuals and society. It frequently presents as a result of a disease or an injury; however, it …

Introduction: Cannabis has been used for medical purposes across the world for centuries.
As states and countries implement medical and recreational cannabis policies, increasing …

Research into the comorbidity between emotional psychopathology and cigarette smoking
has often focused upon anxiety and depression's manifest symptoms and syndromes, with …

While chronic pain is considered by some to be a CNS disease, little is understood about
underlying neurobiological mechanisms. Addiction models have heuristic value in this …

Population Comprehensive evaluation of chronic pain in older adults is multifaceted.
Objective and Methods Research on chronic pain in older adults needs to be guided by …

Pain and substance use are highly prevalent and co-occurring conditions that continue to
garner increasing clinical and empirical interest. Although nicotine and tobacco, alcohol …

Pain and alcohol use are both highly prevalent in the general population, and pain–alcohol
interrelations are of increasing empirical interest. Previous research has identified …

Suicidality is exceedingly prevalent in pain patients. Although the pathophysiology of this
link remains unclear, it may be potentially related to the partial congruence of physical and …

Chronic pain is a significant public health concern that imposes substantial burdens on
individuals and healthcare systems, and factors that contribute to the development and …

Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …