Tackling the emerging threat of antifungal resistance to human health

MC Fisher, A Alastruey-Izquierdo, J Berman… - Nature reviews …, 2022 - nature.com
Invasive fungal infections pose an important threat to public health and are an under-
recognized component of antimicrobial resistance, an emerging crisis worldwide. Across a …

Multidrug resistance (MDR): A widespread phenomenon in pharmacological therapies

A Catalano, D Iacopetta, J Ceramella, D Scumaci… - Molecules, 2022 - mdpi.com
Multidrug resistance is a leading concern in public health. It describes a complex phenotype
whose predominant feature is resistance to a wide range of structurally unrelated cytotoxic …

The rapid emergence of antifungal-resistant human-pathogenic fungi

SR Lockhart, A Chowdhary, JAW Gold - Nature Reviews Microbiology, 2023 - nature.com
During recent decades, the emergence of pathogenic fungi has posed an increasing public
health threat, particularly given the limited number of antifungal drugs available to treat …

Climate change and the emergence of fungal pathogens

NE Nnadi, DA Carter - PLoS pathogens, 2021 - journals.plos.org
The role of the environment in emerging and reemerging infectious diseases is increasingly
recognized [1, 2]. Climate change, defined by the United Nations Framework Convention on …

[HTML][HTML] Multidrug-resistant Candida auris infections in critically ill coronavirus disease patients, India, April–July 2020

A Chowdhary, B Tarai, A Singh… - Emerging infectious …, 2020 - ncbi.nlm.nih.gov
Abstract In New Delhi, India, candidemia affected 15 critically ill coronavirus disease
patients admitted to an intensive care unit during April–July 2020. Candida auris accounted …

The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives

C d'Enfert, AK Kaune, LR Alaban… - FEMS microbiology …, 2021 - academic.oup.com
Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …

[HTML][HTML] Invasive candidiasis

PG Pappas, MS Lionakis, MC Arendrup… - Nature Reviews …, 2018 - nature.com
Invasive candidiasis is an important health-care-associated fungal infection that can be
caused by several Candida spp.; the most common species is Candida albicans, but the …

[HTML][HTML] Resistance of Candida to azoles and echinocandins worldwide

KE Pristov, MA Ghannoum - Clinical Microbiology and Infection, 2019 - Elsevier
Background Recently there has been an increase in Candida infections worldwide. A
handful of species in the genus Candida are opportunistic pathogens and have been known …

[HTML][HTML] Immune defence to invasive fungal infections: A comprehensive review

B Pathakumari, G Liang, W Liu - Biomedicine & Pharmacotherapy, 2020 - Elsevier
The fungal infections are relatively common in humans that can range from common, mild
superficial infections to life-threatening invasive infections. Most of the pathogenic fungi are …

[HTML][HTML] Potential fifth clade of Candida auris, Iran, 2018

NA Chow, T de Groot, H Badali… - Emerging infectious …, 2019 - ncbi.nlm.nih.gov
Four major clades of Candida auris have been described, and all infections have clustered
in these 4 clades. We identified an isolate representative of a potential fifth clade, separated …