In a typical high-throughput drug screening (HTS) process, up to millions of chemical
compounds are applied to cells cultured in well plates, aiming to find molecules that exhibit …

Since its introduction as a genetic model organism, Caenorhabditis elegans has yielded
insights into the causes of aging. In addition, it has provided a molecular understanding of …

The roundworm C. elegans is a mainstay of aging research due to its short lifespan and
easily manipulable genetics. Current, widely used methods for long-term measurement of C …

Biogenic amines are conserved signaling molecules that link food cues to behavior and
metabolism in a wide variety of organisms. In the nematode Caenorhabditis elegans, the …

Many cell types display the remarkable ability to alter their cellular phenotype in response to
specific external or internal signals. Such phenotypic plasticity is apparent in the nematode …

In response to environments that cause cellular stress, animals engage in sleep behavior
that facilitates recovery from the stress. In Caenorhabditis elegans, stress-induced sleep …

The conservation of sleep among animals suggests that this behavior serves an important
adaptive function; however, a unifying function for and genetic..... Stress-induced sleep (SIS) …

Animals optimize survival and reproduction in part through control of behavioral states,
which depend on an organism's internal and external environments. In the nematode …

Better methods are required to interpret the pathogenicity of disease-associated variants of
uncertain significance (VUS), which cannot be actioned clinically. In this study, we explore …

Microbes are an integral part of life on this planet. Microbes and their hosts influence each
other in an endless dance that shapes how the meta-organism interacts with its …