Breast cancer (BC) is the most frequent cancer diagnosed in women worldwide. This
heterogeneous disease can be classified into four molecular subtypes (luminal A, luminal B …

Hypoxia-inducible factors (HIFs) are master regulators of oxygen homeostasis that match O2
supply and demand for each of the 50 trillion cells in the adult human body. Cancer cells co …

The reception and integration of the plethora of signals a cell receives from its
microenvironment determines the cell's fate. CD44 functions as a receptor for hyaluronan …

Breast cancer is now the most frequently diagnosed cancer and leading cause of cancer
death in women worldwide. Strategies targeting the primary tumour have markedly …

Increased expression of CD47 has been reported to enable cancer cells to evade
phagocytosis by macrophages and to promote the cancer stem cell phenotype, but the …

Abstract MicroRNA-155 (miR-155) is frequently upregulated in various types of human
cancer; however, its role in cancer angiogenesis remains unknown. Here, we demonstrate …

Metabolic alterations are one of the hallmarks of cancer, which has recently gained great
attention. Increased glucose absorption and lactate secretion in cancer cells are …

Background: CD44 is widely used as a putative cancer stem cells (CSCs) marker for
colorectal cancer (CRC). However, the prognostic role of CD44 in CRC remains …

Increasing evidence indicates that several types of solid tumor are hierarchically organized
and sustained by a distinct population of cancer stem cells (CSCs). CSCs possess …

Abstract Background Hypoxia-inducible factors (HIFs) are well-established mediators of
tumor growth, the epithelial to mesenchymal transition (EMT) and metastasis. In several …