NMR spectroscopy captures the essential role of dynamics in regulating biomolecular function
TR Alderson, LE Kay - Cell, 2021 - cell.com
Biomolecules are in constant motion. To understand how they function, and why
malfunctions can cause disease, it is necessary to describe their three-dimensional …
malfunctions can cause disease, it is necessary to describe their three-dimensional …
Heteronuclear multidimensional NMR experiments for the structure determination of proteins in solution employing pulsed field gradients
M Sattler, J Schleucher, C Griesinger - Progress in nuclear magnetic …, 1999 - Elsevier
6. 3D and 4D NOESY/ROESY experiments............................................ 146 6.1. 13C-and 15N-
edited NOESY/ROESY experiments.................................. 146 6.2. Filtered experiments for …
edited NOESY/ROESY experiments.................................. 146 6.2. Filtered experiments for …
Refinement of the Cornell et al. nucleic acids force field based on reference quantum chemical calculations of glycosidic torsion profiles
M Zgarbová, M Otyepka, J Sponer… - Journal of chemical …, 2011 - ACS Publications
We report a reparameterization of the glycosidic torsion χ of the Cornell et al. AMBER force
field for RNA, χOL. The parameters remove destabilization of the anti region found in the ff99 …
field for RNA, χOL. The parameters remove destabilization of the anti region found in the ff99 …
[图书][B] Spin dynamics: basics of nuclear magnetic resonance
MH Levitt - 2008 - books.google.com
Spin Dynamics: Basics of Nuclear Magnetic Resonance, Second Edition is a comprehensive
and modern introduction which focuses on those essential principles and concepts needed …
and modern introduction which focuses on those essential principles and concepts needed …
BioMagResBank
EL Ulrich, H Akutsu, JF Doreleijers… - Nucleic acids …, 2007 - academic.oup.com
The BioMagResBank (BMRB: www. bmrb. wisc. edu) is a repository for experimental and
derived data gathered from nuclear magnetic resonance (NMR) spectroscopic studies of …
derived data gathered from nuclear magnetic resonance (NMR) spectroscopic studies of …
Theory, practice, and applications of paramagnetic relaxation enhancement for the characterization of transient low-population states of biological macromolecules …
Understanding the function of biological macromolecules and their complexes at the
physicochemical level requires knowledge of both their structure and dynamics …
physicochemical level requires knowledge of both their structure and dynamics …
Structural polymorphism of 441-residue tau at single residue resolution
MD Mukrasch, S Bibow, J Korukottu, S Jeganathan… - PLoS …, 2009 - journals.plos.org
Alzheimer disease is characterized by abnormal protein deposits in the brain, such as
extracellular amyloid plaques and intracellular neurofibrillary tangles. The tangles are made …
extracellular amyloid plaques and intracellular neurofibrillary tangles. The tangles are made …
Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution
Protein dynamics are essential for protein function, and yet it has been challenging to
access the underlying atomic motions in solution on nanosecond-to-microsecond time …
access the underlying atomic motions in solution on nanosecond-to-microsecond time …
[HTML][HTML] Structure of Bax: coregulation of dimer formation and intracellular localization
Apoptosis is stimulated by the insertion of Bax from the cytosol into mitochondrial
membranes. The solution structure of Bax, including the putative transmembrane domain at …
membranes. The solution structure of Bax, including the putative transmembrane domain at …
Exploring free-energy landscapes of intrinsically disordered proteins at atomic resolution using NMR spectroscopy
The last 15 years have seen a paradigm shift in our understanding of protein biochemistry,
with the realization that an unexpectedly high fraction of the human genome codes for …
with the realization that an unexpectedly high fraction of the human genome codes for …