Following its transcription, RNA can be modified by> 170 chemically distinct types of
modifications—the epitranscriptome. In recent years, there have been substantial efforts to …

Over 100 types of chemical modifications have been identified in cellular RNAs. While the
5′ cap modification and the poly (A) tail of eukaryotic mRNA play key roles in regulation …

In vitro-transcribed (IVT) mRNAs are modalities that can combat human disease, exemplified
by their use as vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

RNA contains more than 100 distinct modifications that promote the functions of stable
noncoding RNAs in translation and splicing. Recent technical advances have revealed …

Transcription and translation are two main pillars of gene expression. Due to the different
timings, spots of action, and mechanisms of regulation, these processes are mainly …

Gene regulation depends on dynamic and reversibly modifiable biological and chemical
information in the epigenome/epitranscriptome. Accumulating evidence suggests that …

Recent advances in pseudouridine detection reveal a complex pseudouridine landscape
that includes messenger RNA and diverse classes of noncoding RNA in human cells. The …

It is a well‐known fact that RNA is the target of a plethora of modifications which currently
amount to over a hundred. The vast majority of these modifications was observed in the two …

To date, more than 170 chemical modifications have been characterized in RNA, providing a
new layer of gene expression regulation termed the 'epitranscriptome'. RNA modification …

RNA modifications can be added or removed by a variety of enzymes that catalyse the
necessary reactions, and these modifications play roles in essential molecular mechanisms …