The epithelial-mesenchymal transition (EMT) represents a biological program during which
epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is …

Cancer metastasis and therapy resistance are the major unsolved clinical challenges, and
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …

The epithelial-to-mesenchymal transition (EMT) plays a critical role during normal
development and in cancer progression. EMT is induced by various signaling pathways …

High-throughput technologies, offering an unprecedented wealth of quantitative data
underlying the makeup of living systems, are changing biology. Notably, the systematic …

Metabolic plasticity enables cancer cells to switch their metabolism phenotypes between
glycolysis and oxidative phosphorylation (OXPHOS) during tumorigenesis and metastasis …

Elucidating the design principles of regulatory networks driving cellular decision-making has
fundamental implications in mapping and eventually controlling cell-fate decisions. Despite …

Recent preclinical and clinical data suggests enhanced metastatic fitness of hybrid
epithelial/mesenchymal (E/M) phenotypes, but mechanistic details regarding their survival …

INTRODUCTION Modern computing is based on sequential logic, in which the state of a
circuit depends both on the present inputs as well as the input history (memory) …

The epithelial-mesenchymal transition (EMT) is a key process implicated in cancer
metastasis and therapy resistance. Recent studies have emphasized that cells can undergo …

Resistance to anti-estrogen therapy is an unsolved clinical challenge in successfully treating
ER+ breast cancer patients. Recent studies have demonstrated the role of non-genetic (ie …