Abstract Pyrazolo [1, 5-a] pyrimidine scaffold is one of the privileged hetrocycles in drug
discovery. Its application as a buliding block for developing drug-like candidates has …

Scientific community is striving to understand the role of heterocycles and fused
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …

Since Schiff base derivatives have a wide range of biological activities, novel Schiff base
derivatives were designed and synthesized in satisfactory yields. 1H NMR, 13C NMR, IR …

The review integrates and analyzes the published data on the chemical reactivity of α-
cyanothioacetamide, a convenient starting compound for the preparation of activated …

Abstract New series of pyrazolo [1, 5-a] pyrimidine derivatives 7a–i, 11a–c and Schiff bases
13a–c were synthesized and screened for their in vitro antitumor activity against three …

Exploring novel classes of antimicrobial therapeutics is an excellent approach to face the
challenge of microbial resistance. In this context, a novel series of pyrazolo [1, 5-a] …

Pyrazolo [1, 5-a] pyrimidines are the dominant motif of many drugs; for instance, zaleplon
and indiplon are sedative agents and ocinaplon was identified as an anxiolytic agent. The …

In this study, an efficient one‐pot procedure for preparing a new series of pyrazolo [3, 4‐b]
pyridine‐fused pyrimidines was described. The target hybrids were developed through a …

A series of pyrazolo [1, 5-a] pyrimidine linked 2-aminobenzothizole conjugates (6a–t) were
synthesized and evaluated for their anticancer activity against five human cancer cell lines …

Cyanopyrazolo [1, 5-a] pyrimidine derivative 3 reacted with some aromatic aldehydes,
arenediazonium salts, hydrazine hydrate, and guanidine hydrochloride to create a series of …