A walk through tau therapeutic strategies

S Jadhav, J Avila, M Schöll, GG Kovacs… - Acta neuropathologica …, 2019 - Springer
Tau neuronal and glial pathologies drive the clinical presentation of Alzheimer's disease
and related human tauopathies. There is a growing body of evidence indicating that …

Advancements and challenges in developing malaria vaccines: Targeting multiple stages of the parasite life cycle

Rajneesh, R Tiwari, VK Singh, A Kumar… - ACS Infectious …, 2023 - ACS Publications
Malaria, caused by Plasmodium species, remains a major global health concern, causing
millions of deaths annually. While the introduction of the RTS, S vaccine has shown promise …

The Need for Novel Asexual Blood-Stage Malaria Vaccine Candidates for Plasmodium falciparum

E Takashima, H Otsuki, M Morita, D Ito, H Nagaoka… - Biomolecules, 2024 - mdpi.com
Extensive control efforts have significantly reduced malaria cases and deaths over the past
two decades, but in recent years, coupled with the COVID-19 pandemic, success has …

First-in-human randomised trial and follow-up study of Plasmodium falciparum blood-stage malaria vaccine BK-SE36 with CpG-ODN (K3)

S Ezoe, NMQ Palacpac, K Tetsutani, K Yamamoto… - Vaccine, 2020 - Elsevier
Background BK-SE36 is blood-stage malaria vaccine candidate that is undergoing clinical
trials. Here, the safety and immunogenicity of BK-SE36 with a novel adjuvant, CpG-ODN …

Plasmodium falciparum Blood Stage Antimalarial Vaccines: An Analysis of Ongoing Clinical Trials and New Perspectives Related to Synthetic Vaccines

DR Salamanca, M Gómez, A Camargo… - Frontiers in …, 2019 - frontiersin.org
Plasmodium falciparum malaria is a disease causing high morbidity and mortality rates
worldwide, mainly in sub-Saharan Africa. Candidates have been identified for vaccines …

[HTML][HTML] Malaria vaccines: facing unknowns

NMQ Palacpac, T Horii - F1000Research, 2020 - ncbi.nlm.nih.gov
Much of the gain in malaria control, in terms of regional achievements in restricting
geographical spread and reducing malaria cases and deaths, can be attributed to large …

Emerging promise of immunotherapy for Alzheimer's disease: a new hope for the development of Alzheimer's vaccine

MT Kabir, MS Uddin, B Mathew, PK Das… - Current topics in …, 2020 - ingentaconnect.com
Background: Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the
characteristics of this devastating disorder include the progressive and disabling deficits in …

Meeting report: WHO consultation on malaria vaccine development, Geneva, 15–16 July 2019

J Vekemans, D Schellenberg, S Benns, K O'Brien… - Vaccine, 2021 - Elsevier
Considerable progress has been made in malaria control in the last two decades, but
progress has stalled in the last few years. New tools are needed to achieve public health …

Identification and validation of a novel panel of Plasmodium knowlesi biomarkers of serological exposure

LS Herman, K Fornace, J Phelan… - PLoS neglected …, 2018 - journals.plos.org
Background Plasmodium knowlesi is the most common cause of malaria in Malaysian
Borneo, with reporting limited to clinical cases presenting to health facilities and scarce data …

Characteristic features of the SERA multigene family in the malaria parasite

N Arisue, NMQ Palacpac, T Tougan, T Horii - Parasites & vectors, 2020 - Springer
Serine repeat antigen (SERA) is conserved among species of the genus Plasmodium. Sera
genes form a multigene family and are generally tandemly clustered on a single …