Neurotrophins have diverse functions in the CNS. Initially synthesized as precursors
(proneurotrophins), they are cleaved to produce mature proteins, which promote neuronal …

The neurotrophins utilize a complex receptor system consisting of Trk receptor tyrosine
kinases and the structurally unrelated tumor necrosis factor receptor family member …

Neurotrophins are growth factors that promote cell survival, differentiation, and cell death.
They are synthesized as proforms that can be cleaved intracellularly to release mature …

Although brain-derived neurotrophic factor (BDNF) regulates numerous and complex
biological processes including memory retention, its extremely low levels in the mature …

The efficient in vivo folding of many heterologous proteins is a major bottleneck of high level
production in bacterial hosts and simple optimisation protocols have not been available yet …

More than 20 matrix metalloproteinases (MMPs) and four of their endogenous tissue
inhibitors (TIMPs) act together to control tightly temporally restricted, focal proteolysis of …

The p75 neurotrophin receptor (p75 NTR) regulates a wide range of cellular functions,
including programmed cell death, axonal growth and degeneration, cell proliferation …

The neurotrophins mediate diverse actions in the developing peripheral and central nervous
systems. They are initially synthesized as precursor forms, or proneurotrophins, that are …

Several lines of evidence support a role for brain-derived neurotrophic factor (BDNF)
alterations in the etiology of eating disorders (EDs). BDNF heterozygous knockout mice …

Autograft is currently the gold standard in the clinical treatment of peripheral nerve injury
(PNI), which, however, is limited by the availability of a donor nerve and secondary injuries …